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. 2022 Aug 12;12:13722. doi: 10.1038/s41598-022-17816-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression levels of hsa_circ_0006423 and miR-492 in NSCLC plasma, tissue samples, and cell lines. (A) Expression levels of hsa_circ_0006423 in the preoperative group were significantly lower than those in the postoperative and the healthy controls group (n = 82), and expression levels of hsa_circ_0006423 in the postoperative group were significantly lower than those in the healthy control group (n = 82). (B) The expression levels of miR-492 in the preoperative group were significantly higher than those in the postoperative and the healthy controls group (n = 82), and the expression levels of miR-492 in the postoperative group were significantly higher than those in the postoperative group the healthy control group (n = 82). (C) Pearson correlation analysis revealed that expression levels of hsa_circ_0006423 and miR-492 in 82 NSCLC plasma samples were negatively correlated. (D) Expression levels of hsa_circ_0006423 in NSCLC tissues were significantly lower than adjacent tissues (n = 82). (E) Expression levels of miR-492 in NSCLC tissues were significantly higher than adjacent tissues (n = 82). (F) Pearson correlation analysis found that the expressions of hsa_circ_0006423 and miR-492 in 82 NSCLC tissue samples were negatively correlated. (G) Pearson correlation analysis found that the expressions of hsa_circ_0006423 in 82 NSCLC plasma and tissue samples were postively correlated. (H) Pearson correlation analysis found that the expressions of miR-492 in 82 NSCLC plasma and tissue samples were postively correlated. (I) Hsa_circ_0006423 in NSCLC cell lines (A549, NCI-H1299 and NCI-H1573) lower expression than the normal bronchial epithelial cell line BEAS-2B. (J) miR-492 in NSCLC cell lines (A549, NCI-H1299 and NCI-H1573) showed higher expression than normal bronchial epithelial cell line BEAS-2B. **P < 0.01; ***P < 0.001.