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. 2022 Aug 12;12:13722. doi: 10.1038/s41598-022-17816-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression levels of hsa_circ_0006423 after upregulation and downregulation of hsa_circ_0006423; effects of hsa_circ_0006423 on NSCLC proliferation. (A) Upregulation effect of hsa_circ_0006423 overexpression plasmid in NSCLC cells. (B) siRNA downregulation effect of hsa_circ_0006423 in NSCLC cells. (C) Expression level of miR-492 before and after overexpression of hsa_circ_0006423. (D) Expression level of miR-492 before and after knockdown of hsa_circ_0006423. (E) Grow curve of A549 cells following overexpression of hsa_circ_0006423. (F) Grow curve of A549 cells following silencing of hsa_circ_0006423. (G) Growth curve of NCI-H1299 cells following overexpression of hsa_circ_0006423. (H) Growth curve of NCI-H1299 cells following silencing of hsa_circ_0006423. ***P < 0.001.