Table 2.
The relationship of hsa_circ_0006423 expression levels (ΔCq) in NSCLC plasmas and tissues with clinicopathological factors of patients with NSCLC.
| Characteristics | n | hsa_circ_0006423 level plasma (tissue) | χ2 test | P value | |
|---|---|---|---|---|---|
| High | Low | ||||
| Total cases | 82 | 41 (41) | 41 (41) | ||
| Gender | 0.467 (0.052) | 0.495 (0.820) | |||
| Male | 51 | 27 (25) | 24 (26) | ||
| Female | 31 | 14 (16) | 17 (15) | ||
| Age (years) | 0.064 (0.071) | 0.800 (0.801) | |||
| ≤ 60 | 21 | 10 (11) | 11 (10) | ||
| > 60 | 61 | 31 (30) | 30 (31) | ||
| Smoking history | 0.507 (1.268) | 0.821 (0.260) | |||
| Yes | 33 | 17 (14) | 16 (19) | ||
| No | 49 | 24 (27) | 25 (22) | ||
| Histology | 0.830 (0.208) | 0.660 (0.649) | |||
| Adenocarcinoma | 38 | 20 (19) | 18 (19) | ||
| Squamous carcinoma | 31 | 16 (17) | 15 (14) | ||
| Large cell lung cancer | 13 | 5 (5) | 8 (8) | ||
| Tumor location | 0.488 (2.390) | 0.825 (0.122) | |||
| Left | 41 | 20 (17) | 21 (24) | ||
| Right | 41 | 21 (24) | 20 (17) | ||
| Differentiation | 12.95 (0.518) | 0.0003 (0.472) | |||
| High and moderate | 57 | 36 (27) | 21 (30) | ||
| Poor | 25 | 5 (14) | 20 (11) | ||
| Tumor size (cm) | 0.734 (9.873) | 0.392 (0.002) | |||
| ≤ 3 | 67 | 32 (28) | 35 (39) | ||
| > 3 | 15 | 9 (13) | 6 (2) | ||
| TNM stage | 0.051 (0.456) | 0.822 (0.499) | |||
| I + II | 33 | 17 (15) | 16 (18) | ||
| III + IV | 49 | 24 (26) | 25 (23) | ||
| EGFR | 0.518 (0.058) | 0.472 (0.810) | |||
| Positive | 25 | 14 (13) | 11 (12) | ||
| Negative | 57 | 27 (28) | 30 (29) | ||
| ALK | 0.576 (0.064) | 0.448 (0.800) | |||
| Positive | 21 | 12 (10) | 9 (11) | ||
| Negative | 61 | 29 (31) | 32 (30) | ||
| PD-L1 | 1.822 (4.100) | 0.177 (0.043) | |||
| Positive | 72 | 34 (33) | 38 (39) | ||
| Negative | 10 | 7 (8) | 3 (2) | ||
EGFR epidermal growth factor receptor, ALK anaplastic lymphoma kinase, PD-L programmed cell death-Ligand 1.
Significant values are in bold.