Fig. 3.

Quantitation of PRR pathway proteins within mouse BMDMs. LC-PRM assays were performed to quantitate proteins of the core TLR4 pathway. In the absence of an LC-PRM measurement, an RNA-seq estimate was used. Selected clusters of nodes are indicated by encircled numbers: 1. TLR receptors, 2. myddosome signaling complex, 3. triffosome signaling complex, 4. NFκB pathway, 5. MAP kinase signaling, 6. gene expression of cytokines, 7. STING and MAVS signaling, 8. inflammasomes, 9. interferon pathway. This signaling network is described in detail in our earlier article¹. n.d., not detected.