TABLE 4|.

Relevant features of the sMRI volumes ranked by the absolute value of their average weighting across 10 folds.

CV penalized EN regularization model
Relevant features	Frequency	$\overline{\mathrm{\beta }}$ × 10−2 a
Right vessel	100	−2.37
Optic Chiasm	98	−0.64
Left Amygdala	99	−0.25
Left Pallidum	100	−0.20
Right Pallidum	100	−0.18
Right choroid plexus	95	−0.15
Right amygdala	93	−0.08
Posterior corpus callosum (CC)	78	−0.07
Cerebrospinal fluid (CSF)	93	0.05
Right ventral diencephalon (DC)	84	−0.05
Left ventral DC	77	−0.02
Right cerebellum white matter (CWM)	90	−0.01

^a Mean weighting of the feature in the penalized EN regularization model. A negative mean weighting indicates a smaller measure in CPHIV than in controls, and adjusted for age at scan, sex, and TIV.