Table 2.
Summary of within treatment efficacy results for hydrogen sulfide levels (log scale) – ITT population
| Timepoint | Treatment | Hydrogen Sulfide – within treatment comparison | |||
|---|---|---|---|---|---|
| Adjusted LS Mean ± SE1 | 95% CI1 | P-value1 | % Change from baseline2 (95% CI) | ||
| 12 hour Overnight | Test | −0.17 ± 0.024 | (−0.22, −0.13) | <0.0001 | −32.989 (−39.84, −25.35) |
| Reference | −0.03 ± 0.023 | (−0.07, 0.02) | 0.2315 | −6.232 (−15.65, 4.24) | |
| Immediately | Test | −1.49 ± 0.022 | (−1.53, −1.45) | <0.0001 | −96.776 (−97.08, −96.44) |
| Reference | 0.03 ± 0.022 | (−0.01, 0.08) | 0.1210 | 8.037 (−2.05, 19.16) | |
| 1 Hour | Test | −0.90 ± 0.043 | (−0.99, −0.82) | <0.0001 | −87.453 (−89.68, −84.74) |
| Reference | −0.08 ± 0.042 | (−0.17, −0.001) | 0.0473 | −17.662 (−32.05, −0.23) | |
| 2 Hour | Test | −0.53 ± 0.037 | (−0.61, −0.46) | <0.0001 | −70.655 (−75.19, −65.29) |
| Reference | −0.09 ± 0.036 | (−0.16, −0.01) | 0.0182 | −18.035 (−30.47, −3.37) | |
| 3 Hour | Test | −0.44 ± 0.039 | (−0.52, −0.36) | <0.0001 | −63.777 (−69.70, −56.70) |
| Reference | −0.07 ± 0.038 | (−0.14, 0.01) | 0.0799 | −14.471 (−28.22, 1.91) | |
1Obtained from ANCOVA with factors for treatment, period, subject (random effect) and baseline (logged) as covariate.
2% Change from baseline is based on antilog value of adjusted LS Mean. A negative difference indicates a reduction.
Test - 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/ sodium fluoride dentifrice.
Reference - Sodium fluoride dentifrice.