Table 4.
Summary of within treatment efficacy results for total VSC levels (log scale) – ITT population
| Timepoint | Treatment | Total VSC – within treatment comparison | |||
|---|---|---|---|---|---|
| Adjusted LS Mean ± SE1 | 95% CI1 | P-value1 | % Change from baseline2 (95% CI) | ||
| 12 hour Overnight | Test | −0.16 ± 0.023 | (−0.21, −0.12) | <0.0001 | −31.169 (−37.97, −23.62) |
| Reference | −0.03 ± 0.022 | (−0.07, 0.02) | 0.2530 | −5.749 (−14.89, 4.37) | |
| Immediately | Test | −1.04 ± 0.029 | (−1.10, −0.98) | <0.0001 | −90.890 (−92.00, −89.62) |
| Reference | 0.04 ± 0.028 | (−0.01, 0.10) | 0.1124 | 10.849 (−2.42, 25.92) | |
| 1 Hour | Test | −0.83 ± 0.036 | (−0.90, −0.76) | <0.0001 | −85.338 (−87.53, −82.76) |
| Reference | −0.11 ± 0.035 | (−0.18, −0.04) | 0.0020 | −22.323 (−33.71, −8.98) | |
| 2 Hour | Test | −0.55 ± 0.034 | (−0.61, −0.48) | <0.0001 | −71.530 (−75.59, −66.80) |
| Reference | −0.09 ± 0.033 | (−0.16, −0.03) | 0.0060 | −19.149 (−30.46, −6.00) | |
| 3 Hour | Test | −0.45 ± 0.037 | (−0.52, −0.38) | <0.0001 | −64.458 (−69.96, −57.95) |
| Reference | −0.08 ± 0.036 | (−0.15, −0.01) | 0.0333 | −16.417 (−29.13, −1.43) | |
1Obtained from ANCOVA with factors for treatment, period, subject (random effect) and baseline (logged) as covariate.
2% Change from baseline is based on antilog value of adjusted LS Mean. A negative difference indicates a reduction.
Test - 0.1% w/w o-cymen-5-ol/ 0.6% w/w zinc chloride/ sodium fluoride dentifrice.
Reference - Sodium fluoride dentifrice.