Table 2.
Details of accepted studies: design; location; application; dosage, and regime
| Study | DS | Study design | Place of study | Application | Xylitol group | Sorbitol group | ||
|---|---|---|---|---|---|---|---|---|
| Dosage | Regime | Dosage | Regime | |||||
| Milgrom et al.20 | 01 | PG | Marshall Islands | Syrup | 4.00 g xylitol, 2.00 g sorbitol | 2× daily xylitol, 1× daily sorbitol | 2.00 g sorbitol, 2.67 g xylitol | 2× daily sorbitol |
| 02 | PG | Marshall Islands | Syrup | 2.67 g xylitol, 2.00 g sorbitol | 3× daily xylitol, 1× daily sorbitol | 2.00 g sorbitol, 2.67 g xylitol | 1× daily xylitol | |
| Mäkinen et al.21 | 03 | PG | Michigan, USA | Chewing gum | 1.3 g pellet gum, 65% xylitol | 5× daily for 5 (10–20) min | 1.3 g pellet gum, 65% sorbitol | 5× daily for 5 (10–20) min |
| Mäkinen et al.22 | 04 | PG | Belize City | Chewing gum | Pellet gum, 65% xylitol | 5× daily for 5 min | Pellet gum, 65% sorbitol | 5× daily for 5 min |
| Mäkinen et al.26 | 07 | PG | Belize City | Chewing gum | 10.7 g pellet gum, 100% xylitol | 3× daily for 5 min | 10.7 g pellet gum, 100% sorbitol | 3× daily for 5 min |
| 08 | PG | Belize City | Chewing gum | 10.7 g pellet gum, 100% xylitol | 5× daily for 5 min | 10.7 g pellet gum, 100% sorbitol | 5× daily for 5 min | |
| 09 | PG | Belize City | Chewing gum | 10.7 g stick gum, 100% xylitol | 3× daily for 5 min | 10.7 g stick gum, 100% sorbitol | 3× daily for 5 min | |
| 10 | PG | Belize City | Chewing gum | 10.7 g stick gum, 100% xylitol | 5× daily for 5 min | 10.7 g stick gum, 100% sorbitol | 5× daily for 5 min | |
| Mäkinen et al.26 | 11 | PG | Stann Creek, Belize | Chewing gum | 10.7 g pellet gum, 100% xylitol | 5× daily for 5 min | 10.7 g pellet gum, 100% sorbitol | 5× daily for 5 min |
| 12 | PG | Stann Creek, Belize | Chewing gum | 10.7 g stick gum, 100% xylitol | 5× daily for 5 min | 10.7 g stick gum, 100% sorbitol | 5× daily for 5 min | |
| Mäkinen et al.23 | 05 | PG | Stann Creek, Belize | Chewing gum | 10.7 g pellet gum, 100% xylitol | 5× daily for 5 min | 10.7 g pellet gum, 100% sorbitol | 5× daily for 5 min |
| 06 | PG | Stann Creek, Belize | Chewing gum | 10.7 g stick gum, 100% xylitol | 5× daily for 5 min | 10.7 g stick gum, 100% sorbitol | 5× daily for 5 min | |
| Hujoel et al.27 | 13 | PG | Stann Creek, Belize | Chewing gum | 10.7 g pellet gum, 100% xylitol | 5× daily for 5 min | 10.7 g pellet gum, 100% sorbitol | 5× daily for 5 min |
| 14 | PG | Stann Creek, Belize | Chewing gum | 10.7 g stick gum, 100% xylitol | 5× daily for 5 min | 10.7 g stick gum, 100% sorbitol | 5× daily for 5 min | |
| Machiulskiene et al.24 | 15 | PG | Kaunas, Lithuania | Chewing gum | Pellet gum, 589 mg xylitol | 5× daily for 10 min | Pellet gum, 589 mg sorbitol | 5× daily for 10 min |
| 16 | PG | Kaunas, Lithuania | Chewing gum | Pellet gum, 589 mg xylitol | 5× daily for 10 min | Pellet gum, 589 mg sorbitol | 5× daily for 10 min | |
| 17 | PG | Kaunas, Lithuania | Chewing gum | Pellet gum, 589 mg xylitol | 5× daily for 10 min | Pellet gum, 589 mg sorbitol | 5× daily for 10 min | |
| Mäkinen et al.25 | 18 | PG | Dayton, OH, USA | Dragees or gum | 8.5 g xylitol per day | 3–5 dragees per day (3 min) or 5× gum daily after meals (15 min) | 8.5 g sorbitol per day | 3–5 dragees per day (3 min) or 5× gum daily after meals (15 min) |
DS, dataset number; PG, parallel group.