Table 1.
MIC, MBC & Synergy of o-cymen-5-ol & zinc gluconate
| Bacterial Species & Strain | Individual MIC (mM) | Combination MIC (mM) | FICI§ | Synergy† | |
|---|---|---|---|---|---|
| o-Cymen-5-ol | Zinc gluconate | o-Cymen-5-ol / Zinc gluconate | |||
| S. mutans NCTC 10449 | 1.66 | 2.76 | 0.83/1.38 | 1.00 | No |
| A. viscosus NCTC 10951 | 3.33 | 11.03 | 1.66/5.51 | 1.00 | No |
| F. nucleatum NCTC 10562 | 3.33 | 5.51 | 0.83/1.38 | 0.50 | Yes |
| P. gingivalis ATCC 53978 | 1.66 | 2.76 | 0.42/0.69 | 0.50 | Yes |
| C. albicans NCPF 3179 | 1.66 | 5.51 | ND | -- | -- |
| Bacterial Species & Strain | Individual MBC (mM) | Combination MBC (mM) | FICI§ | Synergy† | |
|---|---|---|---|---|---|
| o-Cymen-5-ol | Zinc gluconate | o-Cymen-5-ol / Zinc gluconate | |||
| S. mutans NCTC 10449 | 3.33 | 11.03 | 1.66/5.51 | 1.00 | No |
| A. viscosus NCTC 10951 | 6.66 | 11.03 | 3.33/5.51 | 1.00 | No |
| F. nucleatum NCTC 10562 | 3.33 | 22.05 | 1.66/1.38 | 0.56 | No |
| P. gingivalis ATCC 53978 | 3.33 | 11.03 | 0.83/2.76 | 0.50 | Yes |
| C. albicans NCPF 3179 | 3.33 | >44.11 | ND | -- | -- |
*for ease of reference concentrations in toothpaste active system are o-cymen-5-ol = 6.66 mM; zinc gluconate (added as zinc chloride) equivalent to 44.11 mM.
§
FICI = MICo-Cymen-5-ol+Zinc gluconate/MICo-Cymen-5-ol alone + MICZinc gluconate+o-Cymen-5-ol/MICzinc gluconate alone