Table 5.

Treatment comparisons: effect of dentifrice quantity, brushing duration, rinsing regimen, and concentration of F in the dentifrice on log₁₀ area under the curve (AUC_{30–120 min} and log₁₀AUC_{5–120 min}) using adjusted means. Difference is first-named treatment minus second-named treatment, such that a positive difference favours the first-named treatment

Comparison	Log10AUC5–120 min		Log10AUC30–120 min
	Difference, 95% CI*	P-value	Difference, 95% CI*	P-value
1.5 g versus 0.5 g (45 seconds 1 × 15 ml, 1,150 ppm F)	0.28 (0.21, 0.35)	<0.0001	0.27, (0.20, 0.35)	<0.0001
1.5 g versus 0.5 g (60 seconds 1 × 15 ml, 1,150 ppm F)	0.32 (0.25, 0.39)	<0.0001	0.27, (0.19, 0.35)	<0.0001
1.5 g versus 0.5 g (120 seconds 1 × 15 ml, 1,150 ppm F)	0.26 (0.19, 0.33)	<0.0001	0.22, (0.14, 0.29)	<0.0001
1.5 g versus 0.5 g (45–120 seconds, 1,150 ppm F)	0.29 (0.25, 0.33)	<0.0001	0.25, (0.21, 0.30)	<0.0001
1150 ppm F versus 250 ppm F (60 seconds 1.5 g, 1 × 15 ml)	0.58 (0.51, 0.65)	<0.0001	0.44, (0.36, 0.51)	<0.0001
1 × 15 ml versus 3 × 15 ml rinses (60 seconds 1.5 g, 1,150 ppm F)	0.25 (0.18, 0.32)	<0.0001	0.10, (0.03, 0.18)	0.0076
120 seconds versus 45 seconds (0.5 g 1 × 15 ml, 1,150 ppm F)	0.05 (−0.02, 0.12)	0.1804	0.12, (0.04, 0.19)	0.0026
120 seconds versus 45 seconds (1.5 g 1 × 15 ml, 1,150 ppm F)	0.02 (−0.05, 0.09)	0.5063	0.06, (−0.02, 0.14)	0.1305
Overall brushing duration response (0.5 g and 1.5 g doses)		0.4219		0.0063
Linear duration response: 1.5 g dose (45–180 seconds)		0.6612		0.1926

s, seconds.

^*Confidence intervals for the treatment difference between the true means of the two treatments being compared. Significant differences are given in bold type.