Table 4.

Selection of studies reporting on PET/CT-MPs and HP

Year	Author	N	Histology	PET/CT-MP	HP	Association/ Correlation	Purpose	Results
2019	Xu et al	231	Colorectal cancer	MTV, TLG, SUV	NLR, PLR, PLT, LMR	NLR and LMR with SUV, MTV, TLG	Correlation of pre-treatment HPs with PET/CT-MP and estimate the prognostic value of both.	NLR and LMR correlated with SUVmax, MTV, and TLG. NLR in M1 higher than M0. LMR in M1 lower than M0. OS benefit with low MTV, low NLR and high LMR.
2019	Abu-Shawer et al	264	Endometrial, ovarian cervical cancer,	Na	ANC, AMC, MCR PLR, NLR	Na	Association of NLR, MLR, PLR, and OS in advanced gynecological cancers	High baseline NLR (≥ 4.1) and high baseline PLR (≥ 0.3) with more distant metastases
2019	Can et al	129	Invasive ductal carcinoma	MTV, TLG, SUV	MPR, NLR, ER, PR, Her2, Ki67	NLR with SUV and TLG None for ICH	Relation of MTV of primary mass and ALN to molecular subtype, IHC, and inflammatory markers	ALN was associated with MTV and TLG. NLR correlated with primary mass and ALN PET parameters. PET parameters did not change with respect to molecular subtype or IHC markers. Primary mass and ALN metastasis PET parameters showed significant positive correlations for TLG and SUVmax
2019	Mirili et al	54	Small cell lung cancer	MTV, TLG, SUV	NLR	NLR with SUV, TLG, MTV	Evaluation of NLR with PET–CT MPs	NLR ≥ 4, MTV ≥ 60, had lower OS and PFS. Correlation between NLR and SUV, TLG, and MTV
2019	Du et al	89	Cervical cancer	MTV, TLG, SUV	NLR, PLR, HS	NLR and PLR with MTV, TLG, and SCC-ag	Investigation of optimal PET parameters and percentage of SUVmax (%SUVmax) thresholds for tumor recurrence evaluation, and the relationship with hematological parameters in patients with LACC	MTV and TLG had slight-to-moderate correlations with SCC-ag, NLR and PLR
2018	McSorley et al	33	Preoperative colorectal cancer	MTV, TLG, SUV	NLR, mGPS	None	Relationship between PET-CT MPs and host systemic inflammation	There was no association between 18 F-FDG-PET/CT measures of tumor metabolism and systemic inflammation in the 33 preoperative patients
2018	McSorley et al	70	Colorectal cancer (reurrence)	MTV, TLG, SUV	NLR, mGPS	NLR and mGPS with SUV, MTV, TLG	Relationship between PET-CT MPs and host systemic inflammation	Patients with NLR ≥ 5 had a higher SUV, MTV, and TLG. Patients with mGPS of 1–2 had a higher SUV, MTV, and TLG
2015	Sürücü et al	53	Esophageal cancer	MTV, SUV	NLR, PLR, MPN	NLR with MTV. None for SUV	Correlation NLR, PLR, and MPV, with SUVmax, and MTV	NLR was correlated with MTV, SUVmax was not correlated with hematological parameters
2019	Wang et al	122	Non-small cell lung cancer	MTV, SUV	ICH	SUV with IHC, NLR, PLR	Correlation between PET/CT-MP and intra-tumor immunomarkers' expression	SUV values have significant variations for different EGFR statuses (wild vs mutant type), NLR, and PLR. Correlation between SUV and CD8 tumor-infiltrating lymphocytes, CD163 tumor-associated macrophages, and Foxp3-regulatory T cells (Tregs), as well as PD-1 and PD-L1
2021	Present study	71	Head and neck squamous cell carcinoma	SUV, MTV, TLG	NLR, PLR	PLR with MTV and TLG	Correlation between NLR and PLR with SUVmax, SUVmean, MTV, and TLG	PLR correlates with MTV and TLG. SUVmax and SUVmean do not correlate with hematological parameters

Patient number (N), positron emission tomography/computed tomography (PET/CT), metabolic parameter (MP), hematological parameter (HP), standardized uptake value (SUVmax), metabolic tumor volume (MTV), tumor lesion glycolysis (TLG), lymphocyte-to-monocyte ratio (LMR), monocyte-lymphocyte ratio (MLR), immunohistochemistry (ICH), axillary lymph node (ALN), progression-free survival (PFS), overall survival (OS), recurrence-free survival (RFS), squamous cell carcinoma antigen (SCC-ag), modified Glasgow Prognostic Score (mGPS), epidermal growth factor receptor (EGFR), tumor-associated macrophages (TAMs), mean platelet volume (MPV), not applicable (na)