Table 2.

Differentially expressed proteins in SFTS patients

Uniprot_Id	Description	Gene	Recovered patients/normal subjects		Deceased patients/recovered patients
			p-value	log2FC	p-value	log2FC
Complement system
P09871	Complement C1s subcomponent	C1S	1.0E−05	5.666	2.2E−07	− 5.847
P13671	Complement component C6	C6	3.2E−06	− 1.882	0.0031	− 4.564
P10643	Complement component C7	C7	0.0168	− 1.125	0.0008	− 4.422
A0A3B3ISR2	Complement subcomponent C1r	C1R	2.2E−05	5.615	7.9E−06	− 2.897
P0C0L5	Complement C4-B	C4B	0.0092	0.867	0.0002	− 1.774
P0C0L4	Complement C4-A	C4A	4.8E−07	2.138	0.0001	− 1.44
P02748	Complement component C9	C9	0.4626	− 0.243	0.024	− 1.089
P11215	Integrin alpha-M	ITGAM			0.4126	− 0.598
Q5SR44	Complement receptor type 1	CR1			0.1442	1.494
O00187	Mannan-binding lectin serine protease 2	MASP2	0.0048	1.702	0.0323	4.416
Coagulation system
A0A3B3ISJ1	Vitamin K-dependent protein S	PROS1	1.7E−05	2.286	1.7E−10	− 6.992
E7END6	Vitamin K-dependent protein C	PROC	0.0008	2.107	1.4E−05	− 4.393
P05546	Heparin cofactor 2	SERPIND1	0.716	− 0.111	0.0021	− 3.98
P01023	Alpha-2-macroglobulin	A2M	0.4494	0.121	0.0026	− 3.198
P12259	Coagulation factor V	F5	0.1737	1.225	0.0159	− 2.542
P04275	von Willebrand factor	VWF	0.5524	0.697	0.1201	− 1.945
P00740	Coagulation factor IX	F9	0.0348	1.425	0.0194	− 1.564
P01009	Alpha-1-antitrypsin	SERPINA1	0.4545	− 0.447	0.8891	0.092
P01008	Antithrombin-III	SERPINC1	0.2133	− 0.525	0.4596	0.272
P08697	Alpha-2-antiplasmin	SERPINF2	0.0001	− 2.042	0.273	0.541
P05154	Plasma serine protease inhibitor	SERPINA5	0.8133	− 0.168	0.0001	5.42
Downstream target of TNF-α and IL-1β
P05109	Protein S100-A8	S100A8	0.0065	3.536	0.0445	3.82
P06702	Protein S100-A9	S100A9	0.0005	4.66	0.0708	2.681
P02647	Apolipoprotein A-I	APOA1	0.0077	− 0.859	0.0003	− 3.788
P02649	Apolipoprotein E	APOE	0.0525	0.935	1.1E−07	− 5.696