Table 2.
Univariate and Multivariate Cox Regression Analysis of BNP Groups With Outcome of Stroke
| Sensitivity analyses | Cases (%) | Person‐years | Incidence rate, per 100 person‐years | Unadjusted HR (95% CI), P value | Adjusted HR (95% CI), P value |
|---|---|---|---|---|---|
| All included patients,* n=799 | 34 (4.26) | 2238.51 | 1.52 | ||
| BNP≤278 pg/mL, n=438 | 9 (2.05) | 1304.94 | 0.69 | Ref | Ref |
| BNP>278 pg/mL, n=361 | 25 (6.93) | 933.57 | 2.68 | 3.88 (1.81–8.31), 0.001¶ | 3.24 (1.49–7.06), 0.003¶ |
| Excluding patients with AF,† n=469 | 13 (2.77) | 1333.52 | 0.97 | ||
| BNP≤278 pg/mL, n=278 | 4 (1.44) | 829.49 | 0.48 | Ref | Ref |
| BNP>278 pg/mL, n=191 | 9 (4.71) | 441.03 | 2.04 | 3.64 (1.12–11.82), 0.032¶ | 3.42 (1.02–11.48), 0.047¶ |
| Excluding patients from Russia/Georgia,‡ n=695 | 31 (4.46) | 1987.47 | 1.56 | ||
| BNP≤278 pg/mL, n=373 | 8 | 1144.51 | 0.70 | Ref | Ref |
| BNP>278 pg/mL, n=322 | 23 | 842.96 | 2.73 | 3.93 (1.76–8.79), 0.001¶ | 3.28 (1.44–7.47), 0.005¶ |
| Excluding patients treated with warfarin,§ n=537 | 17 (3.17) | 1489.30 | 1.14 | ||
| BNP≤ 278 pg/mL, n=305 | 5 | 908.05 | 0.55 | Ref | Ref |
| BNP>278 pg/mL, n=232 | 12 | 581.25 | 2.06 | 3.67 (1.29–10.44), 0.015¶ | 3.42 (1.16–10.13), 0.026¶ |
| Propensity score matched‖ | |||||
| BNP≤278 pg/mL, n=305 | 6 | 929.21 | 0.65 | Ref | Ref |
| BNP>278 pg/mL, n=232 | 22 | 808.03 | 2.72 | 4.17 (1.69–10.29), 0.002¶ | 4.12 (1.66–10.24), 0.002¶ |
P≤0.05 is statistically significant. AF indicates atrial fibrillation; BNP, B‐type natriuretic peptide; HR, hazard ratio; and Ref, reference.
HR adjusted for age, sex, previous stroke, diabetes, previous myocardial infarction, AF, smoking, spironolactone using, New York Heart Association function class, warfarin, aspirin, estimated glomerular filtration rate.
HR adjusted for previous myocardial infarction, age, sex, previous stroke, diabetes, smoking, spironolactone using, New York Heart Association function class, warfarin, aspirin, estimated glomerular filtration rate.
HR adjusted for age, sex, previous stroke, diabetes, previous myocardial infarction, AF, smoking, spironolactone using, New York Heart Association function class, warfarin, aspirin, estimated glomerular filtration rate.
HR adjusted for age, sex, previous stroke, diabetes, previous myocardial infarction, AF, smoking, spironolactone using, New York Heart Association function class, aspirin, estimated glomerular filtration rate.
HR variables including age, sex, body mass index, ejection fraction, estimated glomerular filtration rate, history of AF; administration of diuretic and β‐blocker was included in the propensity score. Adjusted for previous stroke, diabetes, previous myocardial infarction, smoking, spironolactone, New York Heart Association function class, warfarin, aspirin.
P<0.05.