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. 2022 Jul 25;11(15):e025841. doi: 10.1161/JAHA.122.025841

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© 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Study flow is presented. Among the total population of the ILIAS registry (2322 patients with 3046 vessels), patients with unavailable baseline LVEF or CFR data and without follow‐up data were excluded for the current study, leaving 1889 patients with 2492 vessels with clinical outcomes during 5 years of follow‐up. CFR indicates coronary flow reserve; ILIAS (Inclusive Invasive Physiological Assessment in Angina Syndromes) registry; LVEF, left ventricular ejection fraction; and TVF, target vessel failure.