Table 3.
Clinical Outcomes Over 5 Years of Follow‐Up According to LVEF or CFR
| Clinical outcomes |
LVEF ≥50% (n=2290) |
LVEF <50% (n=202) |
Univariable HR (95% CI) | Multivariable HR* (95% CI)* | P value |
|---|---|---|---|---|---|
| Target vessel failure | 162 (9.2%) | 23 (14.9%) | 1.589 (0.961–2.628) | 1.386 (0.677–2.840) | 0.372 |
| All‐cause death | 80 (4.7%) | 14 (9.8%) | 1.960 (1.092–3.519) | 1.322 (0.550–3.178) | 0.533 |
| Cardiac death | 57 (3.4%) | 10 (6.9%) | 1.953 (0.965–3.952) | 1.265 (0.417–3.842) | 0.678 |
| Target vessel myocardial infarction | 28 (1.6%) | 10 (6.8%) | 4.037 (1.642–9.928) | 3.257 (1.044–10.167) | 0.042 |
| Target vessel revascularization | 116 (6.5%) | 9 (6.3%) | 0.875 (0.418–1.832) | 0.557 (0.159–1.957) | 0.362 |
| Clinical outcomes |
CFR >2.0 (n=1721) |
CFR ≤2.0 (n=771) |
Univariable HR (95% CI) | Multivariable HR* (95% CI)* | P value |
|---|---|---|---|---|---|
| Target vessel failure | 101 (7.7%) | 84 (14.6%) | 2.071 (1.528–2.806) | 2.080 (1.386–3.122) | <0.001 |
| All‐cause death | 45 (3.7%) | 49 (8.6%) | 2.738 (1.785–4.200) | 2.113 (1.215–3.677) | 0.008 |
| Cardiac death | 34 (2.7%) | 33 (6.3%) | 2.444 (1.472–4.057) | 1.906 (1.031–3.526) | 0.040 |
| Target vessel myocardial infarction | 20 (1.6%) | 18 (3.3%) | 2.237 (1.114–4.491) | 3.693 (1.348–10.116) | 0.011 |
| Target vessel revascularization | 66 (5.0%) | 59 (10.2%) | 2.213 (1.531–3.198) | 2.574 (1.557–4.255) | <0.001 |
CFR indicates coronary flow reserve; FFR, fractional flow reserve; HMR, hyperemic microvascular resistance; HR, hazard ratio; IMR, index of microcirculatory resistance; LVEF, left ventricular ejection fraction; and PCI, percutaneous coronary interventions.
*
Adjusted covariables were age, sex, diabetes, previous myocardial infarction, acute coronary syndrome, multivessel disease, target vessel intervention, pre‐PCI diameter stenosis, FFR ≤0.80, IMR ≥25, or HMR ≥2.5.