Table 5.
Independent Predictors for Target Vessel Failure
| Variable | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| CFR ≤2.0 | 2.070 (1.550–2.766) | <0.001 | 2.081 (1.385–3.126) | <0.001 |
| LVEF <50% | 1.589 (0.961–2.628) | 0.040 | 1.381 (0.681–2.800) | 0.371 |
| Age | 1.019 (1.001–1.037) | 0.035 | 1.022 (0.998–1.045) | 0.069 |
| Male | 1.368 (0.901–2.077) | 0.142 | 1.160 (0.681–1.977) | 0.586 |
| Diabetes | 1.739 (1.247–2.424) | 0.001 | 1.372 (0.871–2.160) | 0.172 |
| Previous myocardial infarction | 1.721 (1.194–2.481) | 0.004 | 1.446 (0.868–2.408) | 0.157 |
| Clinical presentation (ACS) | 1.190 (0.709–1.997) | 0.510 | 0.791 (0.399–1.568) | 0.502 |
| Multivessel disease | 2.049 (1.381–3.039) | <0.001 | 1.223 (0.741–2.017) | 0.431 |
| Target vessel intervention | 1.535 (1.126–2.092) | 0.007 | 0.646 (0.392–1.064) | 0.086 |
| Pre‐PCI diameter stenosis | 1.017 (1.008–1.025) | <0.001 | 1.016 (1.003–1.029) | 0.013 |
| Pre‐PCI FFR (≤0.80) | 2.721 (2.042–3.626) | <0.001 | 1.987 (1.273–3.101) | 0.003 |
| Microvascular dysfunction (IMR ≥25 or HMR ≥2.5) | 0.896 (0.631–1.273) | 0.541 | 0.860 (0.554–1.335) | 0.502 |
ACS indicates acute coronary syndrome; CFR, coronary flow reserve; FFR, fractional flow reserve; HMR, hyperemic microvascular resistance; HR, hazard ratio; IMR, index of microcirculatory resistance; LVEF, left ventricular ejection fraction; and PCI, percutaneous coronary intervention.