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. 2022 Jun 30;67(15):1556–1561. doi: 10.1016/j.scib.2022.06.025

Table 1.

Symptoms of the COVID-19 convalescents during 1 year and 2 years follow-ups.

Item 1 year 2 years P-valuea
n = 76 n = 80
Post-discharge discomfort,bn (%) 46 (60.5) 38 (47.5) 0.103
 Fatigue 25 (33.9) 15 (18.8) 0.043c
 Muscle weakness 19 (25.0) 7 (8.8) 0.007c
 Hair loss 17 (22.4) 7 (8.8) 0.019c
 Sleep difficulties 14 (18.4) 17 (21.3) 0.658
 Hypertension 12 (15.8) 10 (12.5) 0.555
 Decreased appetite 3 (3.9) 4 (5.0) 1.000
 Taste disorder 1 (1.3) 3 (3.8) 0.621
 Smell disorder 1 (1.3) 6 (7.5) 0.117



mMRC score,dn (%)
 0 45 (59.2) 60 (75.0) 0.036c
 1 27 (35.5) 15 (18.8) 0.018c
 2 3 (3.9) 5 (6.3) 0.720
 3 1 (1.3) 0 0.487
 4 0 0 Not applicable



Pain, n (%) 19 (25.0) 10 (12.5) 0.045c
 Joint pain 7 (9.2) 2 (2.5) 0.092
 Myalgia 6 (7.9) 2 (2.5) 0.159
 Chest pain 5 (6.6) 1 (1.3) 0.110
 Headache 2 (2.6) 6 (7.5) 0.278



Circulatory symptoms, n (%) 22 (28.9) 11 (13.8) 0.020c
 Feeling cold 17 (22.4) 3 (3.8) 0.001c
 Excessive sweating when mild exercise/rest/sleep 11 (14.5) 7 (8.8) 0.263
 Palpitations 6 (7.9) 0 0.012c
 Arrhythmia 2 (2.6) 3 (3.8) 1.000



Respiratory symptoms, n (%) 16 (21.1) 24 (30.0) 0.201
 Chest distress 10 (13.2) 6 (7.5) 0.244
 Shortness of breath 6 (7.9) 7 (8.8) 0.847
 Cough 4 (5.3) 8 (10.0) 0.267
 Sore throat or foreign body sensation 4 (5.3) 2 (2.5) 0.434
 Sensitive to dust 0 1 (1.3) 1.000



Gastrointestinal symptoms, n (%) 9 (11.8) 2 (2.5) 0.023c
 Hematochezia 3 (3.9) 0 0.113
 Constipation 3 (3.9) 1 (1.3) 0.358
 Nausea 2 (2.6) 1 (1.3) 0.613



Hemolymphatic symptoms, n (%) 7 (9.2) 0 0.006c
 Gum bleeding 6 (7.9) 0 0.012c
 Jaundice 2 (2.6) 0 0.236



Urinary symptoms, n (%) 6 (7.9) 3 (3.8) 0.319
 Copious urine 3 (4.0) 1 (1.3) 0.358
 Dysuria 1 (1.3) 1 (1.3) 1.000
 Urinary calculi 1 (1.3) 0 0.487
 Limb edema 1 (1.3) 0 0.487
 Proteinuria 0 1(1.3) 1.000



Comorbidities, n (%) 23 (30.3) 16 (20.0) 0.139
 Hypertension 10 (13.2) 8 (10.0) 0.537
 Diabetes 5 (6.6) 4 (5.0) 0.741
 Chronic gastric disease 3 (3.9) 2 (2.5) 0.676
 Chronic pharyngitis 3 (3.9) 1 (1.3) 0.358
 Chronic liver disease 2 (2.6) 2 (2.5) 1.000
 Cardia-cerebrovascular diseases 2 (2.6) 2 (2.5) 1.000
 Lung cancer 2 (2.6) 2 (2.5) 1.000
a

P value of Chi-square/Fisher's exact test between 1 year and 2 years.

b

Overall proportion of convalescents who reported at least one discomfort after discharge.

c

There are significant differences between the two time points (α = 0.05).

d

mMRC score: modified British Medical Research Council score. Percentages may not add up to exactly 100% due to rounding. The higher the score (range 0–4), the more severe the dyspnea.