Table 1.

Included Studies

Authors	Country	Methods	Subject	Summary of Findings
Baggott et al. (2015)	Norway	Descriptive	Children with cancer aged 7-12 years and their parents	Sisom was completed in less than 30 minutes, with a high rating in ease of use and the perceived benefits of parental participants.
Kock et al. (2015)	German	Descriptive	Children aged 15-17 years and family of children	The total scores for the group of children and their families were 130.5 and 131.8, respectively, ranging from 115 - 147. This shows that this software solution has outstanding functionality and ergonomics.
Jibb et al. (2017)	Toronto, Canada, USA	Qualitative	Adolescent aged 12-18 years old	The Pain Squad+ application can be received and completed in an average of 4.3 minutes. There were problems with software malfunctions, lack of interface design and confusing text that need revision.
Bruggers et al. (2018)	Utah, USA	Qualitative and quantitative data	Children, parents, health care provider	The survey picture tool showed that two favorite games were collecting star prizes and terraforming the planet. Travelling from space to the space station was a less attractive component. Two favorite mini-games were the Positron Planet Core Game and the Activity Collecting Game, while the less preferred one was the exercise mini-game, which was the exercise game for choosing healthy foods. The average scores for all statements of the provider and parents were above 3.5 and 3.0, respectively.
Chung et al. (2018)	USA	Mixed methods study	Phase I: HCP and parents of cancer children undergoing treatment. Phase II: 30 parents of children aged 3-17 years who are undergoing cancer treatment	Parents reported high satisfaction with the C-TIPS skills education and training module, stress decreased and relaxation increased significantly (p = 0.004; 0.05).
O'Sullivan et al. (2018)	Toronto, Canada, USA	Cohort	Children with cancer aged 8-18 years	All children understood the application's features, and each of the four concepts was more difficult to understand after using the help menu. 19 out of 20 children think the application was an excellent way to communicate with doctors and nurses.
Cook et al. (2019	USA	Quantitative and qualitative data	Children and adolescent with cancer and bone marrow transplant resipients aged 8-18 years	All children understood the application's features, and each of the four concepts was more difficult to understand after using the help menu. 19 out of 20 children think the application was an excellent way to communicate with doctors and nurses.
Vettese et al. (2019)	USA	Longitudinal study	Children and adolescent with cancer and bone marrow transplant recipients aged 8-18 years	Of the 30 children enrolled, the median day of completing the SPARK application was 5 (range 3-5). Almost all (96.6%) thought that screening for symptoms using SPARK was easy or very easy. All participants understood the SPARK symptom report.
Tsimicalis et al. (2019)	Norway	Qualitative	Children with cancer, aged 6-13 years	Many children (33.85%) conveyed verbal responses to at least one symptom; 1) discussing their thoughts and feelings aloud, 2) categorizing their symptoms as pleasant or unpleasant, 3) reflecting their experiences with various levels of certainty. 23 parents (74%) provided at least one input: 1) clarifying, 2) validating their child's response, 3) guiding their child's response, 4) responding on behalf of their child, and 5) making casual jokes/comments.
Svedberg et al. (2019)	Sweden	Quantitative and qualitative methods	Children aged 0-17 years in four pediatric care centres	The successful implementation of Sisom as an eHealth-based communication tool to strengthen children's participation is following the values and goals of the organization, and the beliefs and expectations of health professionals on the benefits of using Sisom.
Schwartz et al. (2020)	Philadelphia	Pilot RCT	61 AYA (12-25 years)	The THRIVE intervention showed a high level of acceptance and feasibility. 71% of knowledge in the intervention group increased. AYA in the intervention group who chose to increase fruit/vegetable consumption rose by 29% compared to the control group by 15%. One person who decided to quit smoking in the intervention group reported not smoking anymore.
Park et al. (2020)	Korea	Qualitative (focus group discussion)	Analysis phase: 12 adolescents with cancer. Design phase: Four specialists in pediatric hematology-oncology unit with ten years of work experience; 2 nurses with master's education in pediatric nursing; 3 doctors with doctoral education. Testing phase: two experts in usability and computer-human interaction. 11 children aged 13-18 years, with a cancer diagnosis and any treatment.	Adolescents with cancer showed an interest in seeing success stories of childhood cancer and self-management after discharge and preferred multimedia content (video clips) over text. The heuristic and user tests identified usability issues and then revised them to make them usable and valuable for cancer adolescents.
Watling et al. (2020)	Canada, USA	Qualitative	Family members (≥ 16 years) of pediatric patients undergoing cancer treatment were 100 people	SPARK family member was easy to use and understand.
Gilljam et al. (2020)	Sweden	A quasi-experimental design with mixed methods	14 children aged 6-12 years	Children's participation based on Shier's participation model was in the first three levels. Children were listened to encouraged to express their opinions, and children's views are taken into account. The proportion of pediatricians directing discussion in the intervention group was more significant (731 occasions) than in the control group (624 events). The ratio of appointment times was almost the same between the two groups (mean 17.0 minutes vs. 17.6 minutes).

USA, United States of America; HCP , Health Care Providers; C-TIPS, Cancer-Tailored Intervention for Pain and Symptoms; SPARK, Supportive Care Prioritization, Assessment, and Recommendation for Kids; RCT, Randomized-controlled trial; AYA, Adolescents and Young Adults