Table 3.
Frequency of Chromosomal Aberrations Induced in Mouse Spleen Cells after Treatment with CP and LAEO
| Treatment and doses | Total abnormal metaphases | No and (%) of metaphases with different types of chromosome aberrations |
Inhibitory index | ||||
|---|---|---|---|---|---|---|---|
| No | Mean% ± S.E | Gap | Fragment and/or Break and/or Break | Multiple aberrations | RT | ||
| I. Control (Non- treated) | 10 | 2.0±0.31a | 5 (1.0) | 5 (1.0) | - | - | - |
| II. Control plant LAEO (0.8 ml /kg) | 7 | 1.40±0.24a | 1 (0.20) | 6 (1.20) | - | - | - |
| III. CP (25mg/kg )Positive control | 186 | 37.20±1.02e | 3 (0.60) | 53 (10.60) | 129 (25.80) | 1 (0.20) | - |
| IV-VI . CP+LAEO | |||||||
| +0.4ml /kg | 161 | 32.20±0.8d | 9 (1.80) | 66 (13.20) | 91 (18.20) | 1 (0.20) | 14 |
| +0.6ml /kg | 112 | 22.40± 0.51c | 4 (0.80) | 50 (10.0) | 56 (11.20) | 2 (0.40) | 42 |
| +0.8 ml /kg | 70 | 14.0±0.71b | 5 (1.0) | 23 (4.60) | 42 (8.40) | - | 66 |
A total of 500 cells were analyzed (5 mice per group; 100 cells/mouse). RT, Robertsonian translocation; One way ANOVA–Tukey’s multiple comparisons test was used. The values having different superscript letters in each column are significantly different from one another.