Table 2.

Univariate and Multivariate Analyses for Overall Survival (A) and Progression-Free Survival (B) (Cox Proportional Hazard Model)

A		Univariate analysis			Multivariate analysis		P value
		HR	95% CI	P value	HR	95% CI
Age	<65 vs. ≥65	1.592	0.961–2.638	0.071	1.669	0.992–2.808	0.054
Gender	Female vs. male	1.302	0.664–2.554	0.443	1.377	0.699–2.713	0.355
T stage	T1–2 vs. T3–4	2.065	1.235–3.455	0.006**	1.563	0.897–2.722	0.115
N stage	N0 vs. N1–3	1.75	0.968–3.165	0.064	1.795	0.947–3.402	0.073
Stage	I–II vs. III–IV	1.792	0.913–3.518	0.09
TIL	Low vs. high	0.452	0.241–0.846	0.013*	0.495	0.259–0.944	0.033*
B		Univariate analysis			Multivariate analysis		P value
		HR	95% CI	P value	HR	95% CI
Age	<65 vs. ≥65	1.125	0.730–1.734	0.593	1.163	0.741–1.826	0.51
Gender	Female vs. male	1.358	0.737–2.503	0.327	1.44	0.778–2.666	0.245
T stage	T1–2 vs. T3–4	1.524	0.983–2.362	0.06	1.207	0.752–1.936	0.437
N stage	N0 vs. N1–3	1.464	0.885–2.420	0.137	1.523	0.883–2.627	0.13
Stage	I–II vs. III–IV	1.369	0.783-2.393	0.271
TIL	Low vs. high	0.456	0.267–0.778	0.004**	0.458	0.264–0.793	0.005**

According to multivariate analyses, TILs are independent prognostic factors for both OS (P = 0.033; HR, 0.495, 95% CI, 0.259–0.944) and PFS (P = 0.005; HR, 0.458; 95% CI, 0.264–0.793); CI, confidence interval; HR, hazard ratio; TIL, tumor-infiltrating lymphocyte