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. Author manuscript; available in PMC: 2022 Aug 13.
Published in final edited form as: Ageing Res Rev. 2020 Sep 4;63:101168. doi: 10.1016/j.arr.2020.101168

Fig. 4.

Fig. 4.

Mutation in these nuclear genes are associated with mitochondrial dysfunction and accelerated ovarian aging (mouse model). Mutations in these mitochondrial genes are associated with ovarian aging (multiple species). There is mitochondrial-to-nuclear crosstalk, which induces phenotypic effects on ovarian aging. ROS, Reactive Oxygen Species. bMT, bovine mitochondria; RNR, ribonucleotide reductase; ND1, NADH-ubiquinone oxidoreductase chain 1; cytochrome oxidase subunit 1; ATP, adenosine triphosphate; CYB, Cytochrome B.