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. 2022 Aug 1;2022:9764002. doi: 10.1155/2022/9764002

Figure 1.

Figure 1

Upregulation of PD-1 in lymphocytes and monocytes of patients with COVID-19. Strategy of the analyses for TCD4+, TCD8+, CD19+, and monocytes expressing PD-1 (a); absolute values of total lymphocytes in patients with moderate (n = 19), severe (open symbol, n = 16), and critical (red symbol, n = 6) disease and healthy control (n = 13) (b). Frequency of total lymphocytes (c), CD4+ CD3+ T-cells (d), CD4+ PD-1+ T-cells (e), CD8+ CD3+ T-cells (f), CD8+ PD1+ T-cells (g), CD19+ cells (h), CD19+ PD-1+ cells (i), total monocyte frequency (j), and CD14+ PD-1+ cells (k) assessed by flow cytometry in peripheral blood samples of control subjects (n = 8) and patients in moderate (n = 18), severe (open symbol, n = 7), and critical (red symbol, n = 7) clinical status. ∗P ≤ 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.