Table 2:

NLRP12 as an inflammasome

Triggers	Inflammasome activation
	In vitro	In vivo	Reference
Yersinia pestis Y. enterocolitica Y. pseudotuberculosis	• Reduced IL-1β and IL-18 production in murine Nlrp12−/− peritoneal macrophages and BMDMs upon infection with virulent and attenuated Y. pestis strains. • Decreased caspase-1 and IL-1β cleavage in murine Nlrp12−/− BMDMs upon infection with attenuated Y. pestis. • Reduced IL-1β production in murine Nlrp12−/− BMDMs upon infection with Y. enterocolitica and Y. pseudotuberculosis.	• Decreased expression of active caspase-1 in bone marrow cells, and Ly6G- or F4/80positive splenocytes obtained from Nlrp12−/− mice infected with virulent and attenuated Y. pestis strains. • Decreased levels of IL-1β and IL-18 in serum and spleen of Nlrp12−/− mice infected with virulent Y. pestis. • Decreased survival and increased bacterial load in the spleen of Nlrp12−/− mice upon infection with virulent and attenuated strains of Y. pestis strains.	Valdimer et al; 2012
Plasmodium chabaudi	NA	• Decreased expression of active caspase-1 and cell death in splenic macrophages and neutrophils obtained from Nlrp12−/− mice infected with P. chabaudi. • Decreased caspase-1 cleavage in splenocytes of Nlrp12−/− mice infected with P. chabaudi. • Decreased serum IL-1β levels in Nlrp12−/− mice infected with P. chabaudi followed by LPS challenge. • Decreased expression of active caspase-1 in splenocytes and decreased IL-1β levels in serum of Nlrp12−/− mice infected with parasitized red blood cells followed by LPS challenge. • Reduced mortality in Nlrp12−/− mice infected with parasitized red blood cells followed by LPS challenge.	Ataide et al; 2014