Table 1.
Baseline characteristics of studied population. Parameters and SOFA (Sequential Organ Failure Assessment) were reported at inclusion
| Total N = 29 | Non-responders N = 6 | Responders N = 23 | P value | |
|---|---|---|---|---|
| Age, years | 67 [57–71] | 67 [57–68] | 67 [57–71] | 0.85 |
| Male gender | 21 (72.4) | 3 (50) | 18 (78) | 0.30 |
| Body mass index, kg/m2 | 25 [22–28] | 25 [23–28] | 25 [19–29] | 0.92 |
| SAPS II | 57 [45–72] | 46 [44–47] | 61 [50–78] | 0.10 |
| SOFA | 7 [5–9] | 5 [4–6] | 7 [5–10] | 0.03 |
| Comordibities | ||||
| Cardiovascular disease | 5 (17) | 1 (17) | 4 (17) | > 0.99 |
| Hypertension | 18 (62) | 2 (33) | 16 (69) | 0.24 |
| Cirrhosis | 0 | 0 | 0 | – |
| Diabetes mellitus | 12 (41) | 1 (17) | 11 (48) | 0.36 |
| Chronic kidney disease | 5 (17) | 0 (0) | 4 (17) | 0.27 |
| Malignancy | 12 (41) | 3 (67) | 9 (39) | 0.63 |
| Sepsis | ||||
| Proven | 21 (72) | 4 (67) | 17 (74) | |
| Suspected | 8 (35) | 2 (33) | 6 (26) | 0.72 |
| Heart rate, bpm | 109 [95–127] | 124 [89–152] | 106 [95–125] | 0.34 |
| MAP, mmHg | 71 [67–82] | 74 [70–79] | 71 [68–83] | 0.94 |
| Cardiac index, mL/min/m2 | 3.4 [2.7–4.5] | 3.4 [2.6–4.4] | 3.4 [2.6–4.6] | 0.84 |
| CRT fingertip, sec | 3.4 [2.5–4.0] | 2.8 [2.5–3.4] | 3.8 [2.6–4.1] | 0.02 |
| Mottling score | 2 [1–3] | 1.5 [0.75–3.25] | 2 [1–3] | 0.51 |
| Skin temperature, °C | 29.8 [29.2–31.6] | 29.8 [28.8–31] | 29.9 [29.2–31.9] | 0.89 |
| Mechanical ventilation, n (%) | 15 (52) | 1 (17) | 14 (61) | 0.05 |
| Crystalloid infused before inclusion (mL) | 1500 [1000–2500] | 1500 [1000–1800] | 1500 [1000–2200] | 0.67 |
| Norepinephrine | ||||
| Yes, n (%) | 14 (48) | 2 (33) | 12 (52) | 0.41 |
| Dose, μg/kg/min | 0 [0–0.40] | 0 [0–0.38] | 0.10 [0–0.40] | 0.53 |
| Biological parameters | ||||
| Arterial pH | 7.31 [7.26–7.44] | 7.29 [7.10–7.40] | 7.32 [7.27–7.44] | 0.36 |
| Arterial lactate, mmol/L | 2.4 [1.4–3.3] | 2.3 [1.3–3.4] | 2.4 [1.3–3.8] | 0.80 |
| Leukocyte count, G/L | 13.4 [6.6–18.8] | 10.6 [5.5–18.6] | 13.4 [7.0–19.3] | 0.72 |
| Hemoglobin, g/dL | 13.1 [10.3–13.8] | 11.7 [9.2–13.7] | 13.3 [11–13.9] | 0.29 |
| Platelet count, G/L | 172 [105–233] | 161 [107–289] | 172 [105–233] | 0.84 |
| Serum creatinin, μmol/L | 127 [96–189] | 104 [99–117] | 131 [84–241] | 0.18 |
| Sodium, mmol/L | 136 [130–139] | 137 [130–140] | 136 [129–139] | 0.94 |
| Protidemia, g/L | 58 [49–62] | 59 [49–62] | 55 [49–63] | 0.98 |
| Bilirubin, μmol/L | 14 [10–18] | 15 [9–27] | 14 [10–19] | 0.85 |
| C reactive protein, mg/L | 137 [30–390] | 161 [75–282] | 100 [4–398] | 0.76 |
| Procalcitonin, ng/L | 10.3 [2.9–65] | 13.5 [5.7–87.8] | 10.5 [1.2–63.6] | 0.48 |
| Death in ICU, n (%) | 7 (24) | 0 (0) | 7 (30) | 0.12 |
SAPS II (Simplified Acute Physiology Score) was calculated within 24 h of admission. Values are given as median (25th–75th percentiles) and percentage according to data distribution. Comparisons were done using non-parametric Mann Whitney test. Patients’ characteristics
ICU intensive care unit, MAP mean arterial pressure, SAPS Simplified Acute Physiology Score, SOFA Score SOFA (Sequential Organ Failure Assessment), CRT capillary refill time
Bold values indicate statistically differences between groups