Table 2.

Analysis of plasmatic nitrites and cytokines levels according to clinical parameters in untreated NPC patients (n = 45).

	Gender		Age (years)		T classification		N classification		Clinical staging
	Male (n=33)	Female (n=12)	<48 (n=22)	≥48 (n=23)	T1+T2 (n=23)	T3+T4 (n=22)	NO (n=7)	N1+N2+N3 (n=38)	I+II (n=6)	III+IV (n=39)
IFN-γ	50.96 ± 60.03	29 ± 36.47	49.13 ± 57.64	41.25 ± 53.81	57.52 ± 65.43	32.13 ± 39.48	34.51 ± 53.14	47.06 ± 56.06	40.17 ± 68	45.86 ± 54.02
11–10	1.61 ± 2.90	0.3915 ± 1.356	0.705 ± 1.44	1.833 ± 3.341	1.89 ± 3.28	0.65 ± 1.525	1.32 ± 3.5	1.275 ± 2.494	2.32 ± 3.87	1.121 ± 2.410
IL-12p40	130.3 ± 729.7	2.52 ± 8.74	193.3 ± 893.8	3.315 ± 7.30	187.3 ± 873.6	0.925 ± 3.081	1.78 ± 4.70	113.6 ± 680	7.12 ± 12.38	109.9 ± 671.3
IL-12p70	14.83 ± 28.24	1.33 ± 1.73*	5.76 ± 8.79	16.46 ± 33.19	16.71 ± 31.40	5.504 ± 13.89	4.28 ± 3.52	12.51 ± 26.85	14.68 ± 30.05	10.70 ± 24.36
IL-13	2.68 ± 7.86	90.41 ± 281.3	49.09 ± 208.8	4.061 ± 9.196	3.84 ± 9.23	49.32 ± 208.7	140.4 ± 369.8	5.011 ± 17.38	6.40 ± 13.90	29.10 ± 157
IL-17A	39.68 ± 58.07	50.03 ± 84.75	46.16 ± 65.2	38.89 ± 66.74	34.25 ± 33.52	51.01 ± 87.29	36.06 ± 48.37	43.62 ± 68.48	27.86 ± 41.19	44.69 ± 68.43
IL-1ϐ	0.23 ± 0.828	0.63 ± 1.47	0.23 ± 0.92	0.4177 ± 1.147	0.318 ± 0.982	0.34 ± 1.11	0	0.3888 ± 1.116	0.708 ± 1.73	0.27 ± 0.903
IL-4	9.18 ± 27.59	0	4.462 ± 16.34	8.9 ± 29.6	12.50 ± 32.55	0.70 ± 3.276	2.19 ± 5.81	7.566 ± 25.85	2.70 ± 6.63	7.35 ± 25.53
11–6	7.28 ± 15.46	3.21 ± 6.61	3.60 ± 3.47	8.681 ± 18.75	7.38 ± 15.73	4.96 ± 11.48	1.68 ± 1.99	7.028 ± 14.78	3.99 ± 5.01	6.53 ± 14.62
11–8	88.5 ± 259.4	161.5 ± 333.5	117.4 ± 320.4	98.88 ± 239.6	109.9 ± 313	105.9 ± 245.7	45.53 ± 75.52	119.5 ± 301.2	267 ± 603.5	83.49 ± 193.8
IP-10	138 ± 139	877.8 ± 361.4	868.9 ± 363.7	1608 ± 1603*	1031 ± 478.6	1473 ± 1665	887.5 ± 405.9	1313 ± 1309	1059 ± 529.6	1276 ± 1296
MCP-1	573.7 ± 329.1	437.8 ± 231.4	474.8 ± 148.9	597.4 ± 403.5	478.3 ± 186.2	599.3 ± 395.8	328.1 ± 93.34	576 ± 320.5*	374.1 ± 111.5	562.6 ± 323.2
TNF-α	24.76 ± 32.46	32.39 ± 52.32	29.44 ± 46.58	24.27 ± 28.98	30.07 ± 45.25	23.38 ± 29.91	16.63 ± 17.04	28.67 ± 40.85	40.90 ± 69.78	24.63 ± 31.87
VEGF	415.4 ± 516.1	319.1 ± 378	396.8 ± 481.7	383 ± 491	486.1 ± 591.7	288.9 ± 311.6	220.8 ± 147.4	420.8 ± 515	261 ± 217.5	409.5 ± 508.5
NO	31.16 ± 14.66	25.03 ± 9.861	30.67 ± 16.39	28.43 ± 10.83	30.01 ± 15.58	29.02 ± 11.79	32.54 ± 12.42	28.97 ± 14.02	20.92 ± 11.37	30.8 ± 13.68

Abbreviations: NPC, nasopharyngeal carcinoma; IL, interleukin; MCP-1, monocyte chemoattractant protein-1; IP-10, interferon protein-10, TNF-α, tumor necrosis factor- α; IFN-γ, interferon- γ; VEGF, vascular endothelial growth factor; NO, nitric oxide. Asterisks indicate a p value of c 0.05. The statistical analysis between groups was conducted using Mann-Whitney (Mean ± SD).