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. 2022 Aug 14;29:60. doi: 10.1186/s12929-022-00844-9

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Effect of SN in hLRRK2, R1441G HEM and HOM mice SNc region. A Ultrastructural analysis of SN in hLRRK2, R1441G HEM and HOM mice SNc region. Non-Tg and hLRRK2 represent a healthy mitochondrion; HEM and HOM represent a swollen mitochondrion. Selected regions in different magnification images (I, 10,000×; II, 20,000×). Asterisks indicate shrinkage and matrix condensation. HEM, R1441G HEM; HOM, R1441G HOM. B Western blot analysis of mitochondrial fission proteins in the mitochondrial fraction of the whole brain. Equal loading of the gel is demonstrated with Ponceau S staining for mitochondrial protein fragmentation performed on the blot before immunostaining. B Representative western blot for Drp1 and Fis1 expression. Densitometry of the Drp1 (C) and Fis1 (D) blots is shown as the fold increase (HEM or HOM hLRRK2). The figure shows a representative (of two) experiment. Values are means ± SD. *Significant effect, p < 0.05; **significant effect, p < 0.01; ***significant effect, p < 0.005; ****significant effect, p < 0.001