TABLE 3.

Virulence in a systemic mouse model of experimental infection in BALB/c and DBA/2 mice

Challenge dose	Strain	Timea	Fungal burden (log CFU)b in:
			BALB/c mice		DBA/2 mice
			Kidney	Brain	Kidney	Brain
1 × 107	SC5314	1	6.03 ± 0.84	4.47 ± 0.13	NTc	NT
	CNC13	1	4.39 ± 0.24	3.24 ± 0.2	5.27 ± 0.21	3.98 ± 0.13
1 × 106	SC5314	1	5.93 ± 0.18	4.04 ± 0.22	6.02 ± 0.92	3.81 ± 0.16
	CNC13	1	3.26 ± 0.24	1.89 ± 0.31*	4.43 ± 0.09	3.16 ± 0.13
		7	3.94 ± 1.13	*
		60	5.11 ± 0.98**	*
1 × 105	SC5314	1	3.61 ± 0.10	3.34 ± 0.36	5.17 ± 0.76	3.70 ± 0.19
		7	4.10 ± 0.84	*
		60	4.32 ± 1.51*	*
	CNC13	1	2.53 ± 0.21	1.78 ± 0.00**	3.76 ± 0.08	2.35 ± 0.18
		7	*	*	3.60 ± 0.98*	3.34 ± 0.00**
		60	4.98 ± 0.00***	*	4.35 ± 0.35**	*
5 × 104	SC5314	7			6.45 ± 0.56	4.53 ± 0.50
		60	4.87 ± 0.96*	*
	CNC13	1	*	*	3.71 ± 0.73	3.66 ± 0.00**
		7	*	*	*	*
		60	*	*	3.92 ± 0.00**	*

^aDay postchallenge (up to MST) when mice were killed by cervical dislocation for CFU quantification. 

^bOnly log CFU values that are statistically significantly different at P = 0.003 (kidney) and P < 0.0001 (brain) are shown (analysis of variance test with C. albicans strain; covariates were time, mice, and dose). *, some or all mice cleared infection; **, more than 50% mice cleared infection. 

^cNT, not tested.