Table 4.
Model MMSE Outputs of 15 ICI-Related Myocarditis Cases, Comparing 11 Non-Fatal and 4 Fatal Cases
| Patient Group | Non-Fatal ICI-Related Myocarditis | Fatal ICI-Related Myocarditis | ||||||
|---|---|---|---|---|---|---|---|---|
| # Cases in Model Run | 11 | 11 | 4 | 4 | ||||
| Output for | Myocarditis score | Troponin | Myocarditis Score | Troponin | ||||
| Mean Prediction Error per patient | 6% | 8.30% | 21.50% | 14.50% | ||||
| % Improvement over Null | 28.20% | 37.50% | 44.80% | 24.20% | ||||
| Input | Error | Input | Error | Input | Error | Input | Error | |
| Ordered Output | Myocarditis Score | 0.0% | Troponin I | 0.0% | All Kept | 0.0% | Troponin I | 0.0% |
| All Kept | 3.6% | Troponin Score | 0.2% | CPK MB | 0.2% | Troponin Score | 0.7% | |
| Comb Load Myometric | 18.1% | All Kept | 2.1% | CPKMB Score | 0.5% | CPKMB Score | 5.6% | |
| Comb ADV EVT | 19.3% | Comb Load Myometric | 8.6% | ALT Score | 0.7% | All Kept | 5.6% | |
| Calcium | 23.9% | Lactate Score | 15.4% | Troponin Score | 1.4% | CPK MB | 5.9% | |
| Troponin I | 24.8% | Comb LabSignal | 15.5% | QRS | 2.0% | Myocarditis | 6.2% | |
| Troponin Score | 26.0% | Myocarditis Score | 19.5% | Lactate Score | 3.2% | ALT Score | 6.3% | |
| Comb LabSignal | 28.6% | Calcium | 19.9% | QRS Score | 3.2% | QRS Score | 7.1% | |
| Lactate | 28.8% | HCT | 20.1% | Comb Load Myometric | 4.3% | Comb ADV EVT | 7.2% | |
| HCT | 29.9% | ALT Score | 21.1% | Comb LabSignal | 5.6% | Comb Load Myometric | 7.3% | |
| ALT Score | 31.0% | BNP Score | 21.3% | AST | 6.1% | Comb LabSignal | 8.2% | |
| BNP Score | 31.0% | OrganMetric | 21.7% | Myocarditis Score | 6.2% | AST | 10.2% | |
| BPdiast | 33.1% | LDH | 22.6% | AST Score | 6.9% | Lactate Score | 13.5% | |
| Magnesium | 33.2% | BNP | 23.1% | CO2 | 11.6% | AST Score | 14.5% | |
| Platelets | 23.5% | Comb ADV EVT | 12.4% | BNP Score | 16.4% | |||
| PO2 | 34.0% | AST Score | 24.8% | OrganMetric | 20.7% | |||
| Drug dose prednisone | 34.0% | Comb ADV EVT | 25.1% | ADV EVT 3rd heart block | 16.8% | CPK Score | 20.9% | |
| QT interval | 34.1% | ADV EVT Chills | 25.4% | Proton pump inhibitor | 16.9% | |||
| AST Score | 34.3% | BPdiast | 25.7% | OrganMetric | 17.5% | LDH Score | 25.5% | |
| Prednisone Dose | 34.4% | QRS | 25.8% | HCT | 17.7% | Sodium | 26.5% | |
| QRS | 34.4% | PT interval | 26.1% | BNP Score | 18.0% | BPdiast | 26.6% | |
| Platelets | 34.5% | HeartRate | 26.3% | Calcium | 18.1% | WBC Score | 26.7% | |
| QRS Score | 34.6% | ADV EVT Hypothyroidism | 26.3% | BPdiast | 18.7% | Calcium | 28.4% | |
| SpO2 | 34.6% | WBC Score | 26.4% | LDH | 18.8% | HCT | 28.8% | |
| ALT | 34.8% | Immunosuppressant | 26.4% | LDH Score | 18.8% | Immunosuppressant | 29.7% | |
| ADV EVT Myocardial inf | 35.0% | TSH | 26.4% | BNP | 19.3% | BUN | 29.9% | |
| OrganMetric | 35.0% | ADV EVT Diarrhea | 26.4% | WBC Score | 20.1% | MAP | 30.1% | |
| ADV EVT Sepsis | 35.3% | CPK | 26.5% | Blood gas pH | 21.1% | ADV EVT Dyspnea | 30.1% | |
| WBC Score | 35.3% | Glucose | 26.6% | Antibiotic | 21.4% | Neutrophils | 30.3% | |
| O2S | 35.5% | Drug dose prednisone | 26.7% | PCO2 | 22.9% | PR interval | 30.4% | |
| CPKMB Score | 35.5% | ADV EVT Hypotension | 26.7% | Phosphate | 23.2% | Corticosteroid | 30.4% | |
| CPK MB | 35.7% | BUN | 26.7% | Immunosuppressant | 23.4% | Eosinophils | 30.6% | |
| ADV EVT Rash maculopapular | 35.8% | ADV EVT Dyspnea | 23.9% | RBC | 30.6% | |||
| Albumin | 35.8% | Prednisone Dose | 26.9% | CPK Score | 23.9% | RespRate | 30.7% | |
| RBC | 36.1% | Albumin | 26.9% | Corticosteroid | 24.1% | PO2 | 30.7% | |
| FIO2 | 36.2% | Ferritin | 26.9% | HCO3 | 24.8% | ADV EVT Chills | 30.8% | |
| PrednisoneEq Score | 26.9% | Insulin | 25.0% | Magnesium | 30.9% | |||
Abbreviations: CombLoad Myometric, combination myocarditis metric; Comb LabSignal, combination laboratory signal; ADV EVT, adverse event; CombADV EVT, combination adverse event signal; CPK, creatine phosphokinase; CPK-MB, creatine kinase-MB; BNP, B-type natriuretic peptide; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; Alk Phos, alkaline phosphate; BPdiast, diastolic blood pressure; BPsys, systolic blood pressure; HCT, hematocrit; WBC, white blood cells; RBC, red blood cells; SpO2, peripheral O2 saturation; FIO2, fraction of inspired oxygen; PO2, partial pressure of oxygen; HCO3, bicarbonate; TSH, Thyroid-stimulating hormone; BUN, blood urea nitrogen; prednisone eq score, scored steroid dose in mg of prednisone.