Table 5.
Model MMSE Outputs for LOO Analysis of ICI-Related Myocarditis Cases, Comparing 6 Patients Who Had Clinical Resolution of Myocarditis in Response to Prednisone Treatment with 4 Non-Responder
| Patients Included | All Steroid Responders | Patients 1,4,5,8,9 | Patients 1,4,5,8,11 | Patients 1,4,5,9,11 | Patients 1,4,8,9,11 | Patients 1,5,8,9,11 | Patients 4,5,8,9,11 | Non-Responder | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # Cases in Model Run | 6 | 5 | 5 | 5 | 5 | 5 | 5 | 4 | ||||||||
| Mean Prediction error per patient | 3.7% | 4.5% | 4.5% | 3.6% | 4.2% | 4.6% | 4.5% | 7.2% | ||||||||
| % Improvement over Null | 43.07% | 39.78% | 36.21% | 40.02% | 42.06% | 37.88% | 40.00% | 46.43% | ||||||||
| Input | Error | Input | Error | Input | Error | Input | Error | Input | Error | Input | Error | Input | Error | Input | Error | |
| ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | ADV EVT Myocarditis | 0.0% | |
| AllKept | 0.9% | AllKept | 3.4% | AllKept | 14.4% | AllKept | 4.8% | AllKept, | 2.8% | AllKept | 14.6% | AllKept | 3.4% | AllKept | 0.1% | |
| CombLoad MyoMetric, | 32.7% | Comb ADV EVT | 28.8% | Comb ADV EVT | 43.5% | CombLoad MyoMetric | 40.5% | Comb ADV EVT | 28.3% | CombLoad MyoMetric, | 49.1% | CombLoad MyoMetric | 14.2% | CPKMB Score | 0.8% | |
| Comb ADV EVT | 39.0% | CombLoad MyoMetric | 30.8% | CombLoad MyoMetric | 45.4% | Troponin I | 40.7% | CombLoad MyoMetric, |
32.9% | Comb ADV EVT | 58.3% | Troponin I | 24.3% | Lactate | 5.8% | |
| Troponin Score | 41.3% | Troponin Score | 40.9% | Troponin I | 52.0% | Troponin Score | 44.9% | Lactate | 45.9% | Troponin Score | 65.2% | Troponin Score | 24.8% | Lactate Score | 6.2% | |
| Troponin I | 45.0% | Comb LabSignal | 44.3% | ADV EVT Myocardial infarction | 53.0% | BNP | 48.4% | Lactate Score | 46.3% | Troponin I | 69.7% | Lactate | 29.4% | CPK | 9.5% | |
| Comb LabSignal | 49.2% | Prednisone Eq Score | 47.0% | Troponin Score | 53.0% | Comb ADV EVT | 52.9% | AST | 50.1% | Comb LabSignal | 69.9% | Lactate Score | 29.8% | CPK MB | 11.7% | |
| BNP | 51.9% | AST Score | 50.1% | Comb LabSignal, | 54.3% | Comb LabSignal, | 54.8% | Troponin Score | 54.2% | AST Score | 71.7% | CombLab Signal | 31.6% | CombLoad MyoMetric |
11.7% | |
| AST Score | 52.8% | Troponin I | 51.1% | AST Score | 56.2% | Prednisone Eq Score | 55.7% | Troponin I | 54.8% | CPK | 74.8% | Comb ADV EVT | 38.5% | CPK Score | 12.5% | |
| Lactate Score | 52.9% | AST | 51.1% | AST | 56.7% | ALT | 56.7% | AST Score | 56.0% | Lactate | 74.9% | Prednisone Eq Score | 42.3% | ALT Score | 13.8% | |
| CPK Score | 54.0% | CPK | 51.4% | Macrolide | 59.1% | Drug dose prednisone | 58.2% | Comb LabSignal, | 58.4% | CPK Score | 78.4% | BNP | 44.5% | Troponin Score | 14.5% | |
| Lactate | 56.0% | Lactate Score | 51.4% | CPK | 59.5% | AST | 58.5% | ADV EVT Myocardial infarction | 59.1% | ALT | 78.6% | AST Score | 47.3% | Comb ADV EVT | 14.6% | |
| Prednisone Eq Score | 57.4% | Lactate | 52.0% | Penicillin | 60.5% | Drug equiv prednisone | 59.2% | Macrolide | 59.6% | ADV EVT Myocardial infarction | 81.3% | AST | 49.2% | ALT | 15.0% | |
| ADV EVT Myocardial infarction | 57.5% | CPK Score | 52.5% | Drug equiv prednisone | 60.6% | CPK | 59.2% | Drug dose prednisone | 59.8% | Lactate Score | 81.3% | BNP Score | 50.3% | QRS Score | 15.4% | |
| ALT Score | 57.6% | BNP Score | 52.8% | ALT | 61.1% | ALT Score | 59.4% | ALT | 59.8% | AST | 82.0% | ADV EVT Myocardial infarction | 51.0% | Troponin I | 15.6% | |
| AST | 57.8% | Supplement | 52.8% | CPK Score | 62.2% | AST Score | 59.7% | Drug equiv prednisone | 60.0% | SCr | 83.5% | CPK | 51.9% | Comb LabSignal | 22.6% | |
| Drug dose prednisone | 58.0% | ADV EVT Myocardial infarction | 53.4% | BNP | 62.5% | ECHO LVEDV | 60.4% | First generation antipsychotic | 61.0% | Penicillin | 84.3% | Drug equiv prednisone | 52.3% | Prednisone Eq Score | 25.3% | |
| Drug equiv prednisone | 58.3% | Penicillin | 54.5% | ALT Score | 63.0% | CPK Score | 61.0% | ALT Score | 61.0% | Prednisone Eq Score | 84.4% | Drug dose prednisone | 52.8% | BNP Score | 28.4% | |
| Macrolide | 59.5% | Drug equiv prednisone | 54.8% | Antiemetic | 63.0% | Insulin | 61.9% | H 2 antagonist, | 61.0% | Macrolide | 84.9% | Albumin | 54.0% | BNP | 31.3% | |
| CPK | 59.5% | ALT Score | 55.0% | Drug dose prednisone, | 63.2% | QRS Score | 61.9% | SCr | 61.1% | ALT Score | 85.8% | ALT Score | 54.1% | AST | 43.2% | |
| SCr | 60.5% | Drug dose prednisone | 55.0% | SCr | 64.1% | Diag Abnormal ECG | 62.1% | Prednisone Eq Score | 61.2% | BNP | 86.3% | ALT | 54.2% | HeartRate | 43.3% | |
| BNP Score | 61.1% | Macrolide | 55.3% | ADV EVT Neuropathy | 64.2% | ADV EVT Dyspnea | 62.2% | BNP Score | 61.2% | Drug equiv prednisone | 87.0% | Penicillin | 54.4% | AST Score | 43.9% | |
| Penicillin | 61.2% | Tachycardia | 55.6% | Electrolyte | 64.2% | QRS, | 62.3% | Penicillin | 61.4% | Drug dose prednisone | 88.4% | Anticoagulant | 54.7% | O2 Sat | 50.7% | |
| First generation antipsychotic | 62.1% | ALT | 55.7% | First generation antihistamine | 64.3% | s5 HT4 agonist | 62.4% | OrganMetric, | 62.8% | Diag Abnormal ECG | 88.5% | Macrolide | 55.2% | RespRate, | 52.1% | |
| ALT | 62.2% | TSH | 56.3% | Alpha 2 agonist | 64.5% | Beta 1 agonist | 62.6% | Tumor Score | 63.5% | Tachycardia | 88.5% | CPK Score | 55.7% | WBC Score, | 52.3% | |
| Corticosteroid | 62.5% | Prothrombin | 57.4% | Supplement | 64.6% | AG Ratio | 62.6% | ADV EVT Neuropathy | 63.7% | Alpha 2 agonist | 90.0% | Corticosteroid | 56.3% | WBC | 52.8% | |
| H2 antagonist | 62.5% | Neutrohils Band | 57.6% | Tetracycline | 64.6% | SCr | 62.7% | CPK Score | 63.8% | H2 antagonist | 90.1% | Calcium | 56.5% | Immunosuppressant | 53.8% | |
| ADV EVT Neuropathy | 62.9% | AG Ratio | 57.7% | Tumor Score | 64.7% | ADV EVT Sepsis | 62.7% | RBC | 63.9% | AG Ratio | 90.2% | Beta lactam | 56.7% | PO2 | 54.4% | |
| OrganMetric, | 63.0% | SCr | 58.0% | s5 HT3 antagonist | 64.7% | LDH | 62.8% | Tachycardia, | 63.9% | HCT | 90.8% | Tumor Score | 57.0% | Calcium channel blocker | 54.6% | |
| Diag Abnormal ECG | 63.1% | Antihypertensive | 58.7% | First generation antipsychotic | 64.8% | CPK MB | 63.0% | Potassium sparing diuretic, | 64.1% | ADV EVT Neuropathy | 90.8% | Protein | 57.4% | HCO3 | 55.2% | |
| AG Ratio | 63.2% | BNP | 58.7% | TSH | 64.8% | BNP Score | 63.4% | Diag Abnormal ECG | 64.1% | First generation antipsychotic | 90.9% | SCr | 57.5% | LDH Score | 55.6% | |
| Albumin | 63.3% | ADV EVT Neuropathy | 58.9% | Decongestant | 64.8% | LDH Score | 63.6% | Electrolyte | 64.4% | TSH | 91.5% | Tachycardia | 57.9% | Tumor Score | 55.7% | |
| Antidiarrheal | 63.5% | Albumin | 59.0% | Antidiarrheal | 64.9% | Basophils | 63.7% | Antidiarrheal | 64.5% | Prothrombin | 91.5% | OrganMetric | 57.9% | Phosphate | 55.8% | |
| Decongestant | 63.6% | CMRI LVEDV | 59.0% | Pressure support | 65.2% | Prokinetic | 63.9% | First generation antihistamine | 64.6% | Analgesia | 91.6% | ADV EVT Neuropathy | 58.0% | BUN | 55.8% | |
| Potassium sparing diuretic | 63.7% | H2 antagonist | 59.0% | H2 antagonist, | 65.2% | OrganMetric | 64.0% | Neutrophils Band | 91.6% | WBC | 58.3% | |||||
| Antidepressant | 64.0% | Loop diuretic | 58.4% | |||||||||||||
Abbreviations: CombLoad Myometric, combination myocarditis metric; Comb LabSignal, combination laboratory signal; ADV EVT, adverse event; CombADV EVT, combination adverse event signal; CPK, creatine phosphokinase; CPK-MB, creatine kinase-MB; BNP, B-type natriuretic peptide; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; Alk Phos, alkaline phosphate; BPdiast, diastolic blood pressure; BPsys, systolic blood pressure; HCT, hematocrit; SpO2, peripheral O2 saturation; FIO2, fraction of inspired oxygen; PO2, partial pressure of oxygen; HCO3, bicarbonate; LVEDV, left ventricular end diastolic volume; TSH, thyroid stimulating hormone; SCr, serum creatinine; BUN, blood urea nitrogen; AG ratio, albumin/globulin ratio; Diag abnormal ECG, diagnosis of abnormal ECG.