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. 2022 Aug 13;13:4752. doi: 10.1038/s41467-022-32353-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The 96-class contextual mutational spectra for the three mutation patterns (MPs) for the evolved populations with MMR- background or the L10 transfer scheme based on the dimensionality reduction analysis. Each bar represents a class; each class represents a single nucleotide change (one of six colored blocks; labels on the top) with the context of 3′ and 5′ flanking nucleotide (ticks at the bottom). b Three MPs largely contribute to the mutation profiles of clones isolated from the evolved populations with MMR- background or the L10 transfer scheme. c Correlation coefficients between each MP and each of 96-class mutational spectra from various MMR-deficient organisms (G+: Gram-positive bacteria; G-: Gram-negative bacteria). d Correlation coefficients between each MP and each of 96-class spectra for human cancer. SBS6, 14, 15, 20, 21, 26, and 44 are seven MMR-deficient spectra (single base substitutions; SBS) annotated in the human cancer database, COSMIC. For (c, d), the size and colour of circles represent the values of correlation coefficients (r; shown if ≥0.7). Source data are provided as a Source Data file (Data 3).