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. 2022 Aug 13;8:360. doi: 10.1038/s41420-022-01152-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Heatmap of energy metabolites measured by target metabolomics analysis in KCNK3 overexpression groups and control groups. B Metabolic levels of D-glucose 6-phosphate and L-lactate detected by target metabolomics analysis. C Relative glucose uptake and lactate production were measured in KCNK3-overexpressed or control LUAD cells. D, E Western blot analysis of GLUT1 and LDHA protein expressions was performed in KCNK3-overexpressed LUAD cells, with results normalized relative to the expression of GAPDH. F GLUT1 and LDHA immunofluorescence was detected to show the glucometabolic alteration in KCNK3-overexpressed LUAD cells, scale bar 25 µm. (NC negative control, OE overexpression. Data are presented as the mean ± SD of three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).