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. 2022 Aug 13;13(8):703. doi: 10.1038/s41419-022-05157-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A Representative qPCR analysis of SIRT3 and COX10 expression in ZEB1-depletion cell lines. B Immunoblotting for SIRT3 and COX10 in ZEB1-knockdown cells. C, D Four primers were designed to cover the human SIRT3 or COX10 promoter regions and were used to identify ZEB1 binding sites in ChIP assays. E Luciferase reporter assay indicated that the luciferase activity was significantly increased in ZEB1-depletion cells containing the reporters with binding site of SIRT3. F The luciferase activity was significantly decreased in ZEB1-depletion cells containing the reporters with binding site of COX10. (Median values are plotted in the column with data generated from at least three independent biological replicates, statistical analysis was performed by unpaired t-tests. KD knockdown, NC negative control, Si small interferon. The data was presented as mean ± SD, *P < 0.05, **P < 0.01).