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. 2022 Aug 13;13:4760. doi: 10.1038/s41467-022-32530-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Correlation analysis of mRNA levels of GAGs biosynthesis genes identified in Fig. 1c and AR regulated genes (KLK3, TMEFF2, NKX3.1, TMPRSS2, FKBP5). Circle size represents Pearson correlation coefficient absolute values. Blue, negative correlation; Red, positive correlation, VPC cohort (n = 101)³⁹. b Heatmap of gene expression in CRPC patients; (UW cohort; n = 138) [https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147250] (GSE147250). c CHST11 gene expression in untreated (n = 69) and ADT treated PC patients (n = 14) (mean ± SD; two-tailed Mann-Whitney test); d low-risk (LR, n = 22) and high-risk (HR, n = 57) (mean ± SD; two-tailed Mann-Whitney test); e patients with metastases (M; n = 33) and without metastases (NM; n = 58) (mean ± SD; two-tailed Mann-Whitney test). (VPC cohort). f Schematic protocol of PDXs tumor generation for RNA-Seq analysis used in g and h. g CHST11 and KLK3 gene expression in prostate cancer (PC) PDXs before (Pre-Cx) and 12 weeks after castration (Cx-12w). Circle size represents fold change of normalized RNA-Seq counts of Cx-12w compared to Pre-Cx in each PDX. h RNA-Seq gene expression of CHST11 and AR regulated genes in Adeno (n = 26) and relapsed (n = 11) PC PDXs. (mean ± SEM; two-tailed t-test). Source data are provided as a Source Data file.