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. 2022 Aug 13;5:816. doi: 10.1038/s42003-022-03788-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Tumor images (a), tumor growth curves (b), and tumor weights (c) of the xenograft tumors derived from MHCC97H-KD-TDP-43 and MHCC97H-Control cells (n = 6). d The body weights of mice in the indicated groups. IHC staining of Ki67, C-caspase3, p53, and Bcl-2 in mice xenograft tumors (e) and quantitative analysis (f). Scale bar: 50 µm. g, h Overall survival and relapse-free survival were analyzed in HCC cancer patients using the GEPIA (http://gepia.cancer-pku.cn/) and Kaplan–Meier plotter (http://kmplot.com/analysis/) online databases, respectively. Plots were generated based on the expression level of TDP-43 (g plot: logrank P = 0.00059; h plot: logrank P = 0.022). i The expression levels of TDP-43 in liver tumor tissues and normal tissues adjacent to the tumor were counted from GEO database GSE36376. Error bars represent ± s. d. *P < 0.05, **P < 0.01, ***P < 0.001 by two-tailed Student’s t test.