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. 2022 Aug 13;7:287. doi: 10.1038/s41392-022-01119-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Stem cell therapy in liver fibrosis. MSCs isolated from different sources, including umbilical cord, bone marrow, placental, adipose tissue, placental, hair follicle, function to improve liver fibrosis. MSCs reduced hepatocyte damage through immune suppressive pathways, which in turn prevents HSC activation. Furthermore, MSCs increased the phagocytosis of hepatocyte debris by changing macrophage polarity, while increasing matrix metalloproteinase synthesis to remodel extracellular matrix. Created with BioRender