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. 2022 Aug 15;13:4765. doi: 10.1038/s41467-022-32543-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Gross kidney images and H&E-stained kidney sections from 18-week-old mice with the indicated genotypes derived from founder#3. miR-17 motif deletion was associated with sustained benefit and suppressed long-term PKD progression. n = 3 (Pkd1^RC/+), n = 3 (Pkd1^RC∆17/+), n = 8 (Pkd1^RC/-), and n = 7 (Pkd1^RC∆17/-). b KW/BW, BUN, and serum creatinine (Scr) levels in the 18-week-old progeny of founder#3 are shown. c Heatmap showing global mRNA expression profiles of kidneys from 18-day-old mice with the indicated genotypes. mRNAs that were dysregulated in Pkd1^RC/- compared to Pkd1^RC/+ kidneys but exhibited improved expression in Pkd1^RCΔ17/- kidneys were chosen for visualization. #3 = founder#3; #2 = founder#2. n = 3 (Pkd1^RC/+), n = 3 (Pkd1^RC∆17/+ founder 2), n = 3 (Pkd1^RC∆17/+ founder 3), n = 5 (Pkd1^RC/-), n = 5 (Pkd1^RC∆17/- founder 2), and n = 5 (Pkd1^RC∆17/- founder 3). (d) Representative images showing phospho-Histone-H3 (pHH3), Mannose Receptor C-Type 1 (MRC1), or pCreb1 immunostaining in kidney sections of 18-day-old and 18-week-old Pkd1^RC/- (n = 5) and Pkd1^RCΔ17/- (n = 5) mice. The sections were co-labeled with DBA to mark collecting duct-derived cysts. Error bars indicate SEM. Statistical analysis: One-way ANOVA, Tukey’s multiple-comparisons test (b). Source data are provided as a Source Data file.