Figure 5.

Infection symptoms of trial participants versus adult household members

(A) Infection symptoms in BCG and placebo groups compared with non-diabetic adult partners living in the same households. We collected surveys of symptoms of infectious diseases from all trial participants and household members of 13 BCG families and 7 placebo families. The BCG-treated trial participants had comparable or lower total infectious symptoms indexes compared with their partners living in the same household, whereas most placebo-treated trial participants had more severe symptoms compared with their partners. Statistical analysis of the differences by two-sample Wilcoxon testing was significant (two-tailed; p = 0.049; BCG n = 13 and placebo n = 7). Left panel: xy plot of symptom index of trial participants versus their household members. Right panel: the same data are also shown as an xy plot of household members versus the difference of trial participants and their household members. This plot makes it easier to visualize which groups had milder or more severe disease by introducing positive and negative differences.

(B) Distribution of individual infectious disease symptoms in BCG- and placebo-treated participants and infected household members across the four scoring possibilities (0: no symptoms; 1: mild; 2: moderate; 3: severe symptoms). Number at risk data are shown in Figure S4.