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CXCL5 induced in various ways participates in different signaling pathways to promote tumor metastasis. CXCL5-CXCR2 axis is involved in the process of epithelial-mesenchymal transformation (EMT), invasion, and metastasis of cancer cells via the PI3K/AKT/GSK-3β/Snail-Twist pathway, ERK/Elk-1/Snail pathway, as well as JNK and p38 pathways.
