Table 1.
Comparison of clinical data and cognitive function among LAN, RAN, and HC groups.
| LAN (n = 40) | RAN (n = 24) | HC (n = 67) | F/H/T values | p-value | Post-hoc | |
|---|---|---|---|---|---|---|
| Gender (male) | 16 (40.0%) | 5 (20.8%) | 21 (31.3%) | 2.562 | 0.278a | N/A |
| Age (yrs) | 49.00 ± 14.32 | 50.50 ± 12.27 | 46.64 ± 10.06 | 1.105 | 0.334b | N/A |
| Years of education (yrs) | 10.00 (7.80) | 8.50 (8.30) | 9.00 (7.00) | 4.825 | 0.090c | N/A |
| Course of disease (yrs) | 2.00 (5.23) | 2.75 (5.25) | N/A | 1.487 | 0.223d | N/A |
| THI | 14.00 (6.00) | 10.00 (6.00) | N/A | 0.221 | 0.639d | N/A |
| Left PTA (dB HL) | 55.73 ± 26.14 | 22.15 ± 10.67 | N/A | 6.304 | <0.001e* | N/A |
| Right PTA (dB HL) | 17.50 (10.00) | 66.74 ± 34.06 | N/A | −6.031 | <0.001d* | N/A |
| MoCA scores | 21.00 (6.00) | 19.00 (9.00) | 26.00 (5.00) | 37.407 | <0.001c* | RAN < HC LAN < HC |
| RAVLT immediate recall | 34.00 (16.00) | 31.00 (15.00) | 47.00 (19.00) | 31.927 | <0.001c* | RAN < HC LAN < HC |
| RAVLT delay recall | 6.28 ± 3.52 | 5.29 ± 2.97 | 9.06 ± 3.32 | 15.404 | <0.001b* | RAN < HC LAN < HC |
| Stroop A (s) | 32.50 (27.50) | 36.00 (17.50) | 27.00 (12.50) | 10.053 | 0.007c* | RAN>HC |
| Stroop B (s) | 48.50 (33.00) | 54.00 (32.00) | 37.00 (19.00) | 16.996 | <0.001c* | RAN>HC LAN>HC |
| Stroop C (s) | 125.50 (85.00) | 131.00 (64.00) | 86.00 (52.00) | 22.064 | <0.001c* | RAN>HC LAN>HC |
| SDMT | 35.36 ± 15.66 | 31.38 ± 17.06 | 45.16 ± 16.84 | 8.574 | 0.004b* | RAN < HC LAN < HC |
| TMT A (s) | 52.00 (68.00) | 73.50 (62.00) | 38.00 (31.00) | 19.890 | <0.001c* | RAN>HC LAN>HC |
| TMT B (s) | 180.50 (190.00) | 231.00 (191.00) | 104.00 (111.00) | 16.473 | <0.001c* | RAN>HC LAN>HC |
| HAMD | 8.00 (8.00) | 10.00 (5.00) | 2.00 (3.00) | 65.865 | <0.001c* | RAN>HC LAN>HC |
| HAMA | 6.00 (6.00) | 7.00 (6.00) | 2.00 (2.00) | 61.010 | <0.001c* | RAN>HC LAN>HC |
a
p and
b
p-values were obtained by the R × C chi-square test and ANOVA test, respectively.
c
p and
d
p-values were obtained by Kruskal-Wallis and Mann-Whitney (non-parametric test), respectively.
e
p-values obtained by t-test. F values, H values, and T values were obtained by ANOVA, Kruskal-Wallis, and t-test, respectively. All data were expressed as mean ± SD, median (interquartile range), or number (percentage). The significance level was set at p < 0.05.
*
p < 0.05. LAN, left acoustic neuroma; RAN, right acoustic neuroma; HC, healthy controls; PTA, pure tone average; THI, tinnitus handicap inventory; N/A, not available.