Figure 1.

Flowchart of inclusion and exclusion of patients. DEE, Developmental and epileptic encephalopathy; N, number of subjects; Red color, treatable disease; *, Supplementary Table 1. Patients given a genetic diagnoses prior to 2014 and therefore not invited. **, 3/22 of the excluded patients were diagnosed with a genetic cause of disease (SCN1A, AMT, SCN2A); ***, Other disease includes; three patients with structural lesions explaining epilepsy and two with autism spectrum disorder and self-limiting epilepsy.