Figure 5.
YAP1 deficiency aggravated oxidative stress-mediated lung injury in CLP mice. (A) Histological images of lung samples exhibited by HE staining in mice following CLP, YAP1f/f, and CLP+YAP1f/f treatment. (B) The pathological lesion scores. (C) The content of BALF protein. (D) Representative fluorescent images of ROS staining and the quantification of ROS fluorescence intensity in lung tissue. (E) The certification of YAP1 conditional knockout in mice pulmonary epithelial cells. (F–G) Pulmonary content of MDA (F) and GSH (G) was assessed by the corresponding commercial kit. Data are expressed as mean ± SD. n = 6; *p < 0.05, **p < 0.01, ***p < 0.001.