Table 3.

Laboratory parameters of patients with sickle cell disease (SCD) at baseline and follow–up time points.

	Follow–up time points
Laboratory parameters	Baseline (N = 19) Mean ±SE	24 weeks (N = 19) Mean ±SE	Change in mean from baseline to 24 weeks	48 weeks (N = 19) Mean ±SE	Change in mean from baseline to 48 weeks	72 weeks (N = 19) Mean ±SE	Change in mean from baseline to 72 weeks	P *	P
Hemoglobin, g/dL	8.2 ± 0.35	8.7 ± 0.27	0.48 ± 0.20	9.2 ± 0.26	0.92 ± 0.19	8.8 ± 0.33	0.57 ± 0.18	<0.001	0.0008†
Hematocrit, %	24.1 ± 0.92	26.0 ± 0.86	1.86 ± 0.71	27.9 ± 0.83	3.75 ± 0.58	26.6 ± 1.10	2.49 ± 0.76	<0.001	<0.0001†
WBC count, x109/L	11.9 ± 0.97	10.8 ± 1.10	−1.0737 ± 1.24	9.5 ± 0.83	−2.41 ± 0.71	9.6 ± 0.83	−2.32 ± 1.14	0.149	0.0205†
Reticulocyte count, x109/L	284.4 ± 21.72	253.0 ± 19.18	−31.37 ± 21.45	241.6 ± 17.44	−42.8 ± 20.61	203.6 ± 19.85	−80.74 ± 22.39	0.003	0.0121‡
LDH, U/L	561.8 ± 50.68	484.9 ± 43.37	−76.90 ± 38.72	331.2 ± 26.85	−230.63 ± 37.26	436.4 ± 48.95	−125.42 ± 61.89	<0.001	<0.0001†

SE, Standard error.

^*Repeated measures ANOVA.

Pairwise comparison of mean difference (Bonferroni correction):

^†baseline vs. 48 weeks;

^‡baseline vs. 72 weeks.