Table 1.
Minimum inhibition concentration summary for 35 M. salivarium Isolates.
| Reagent | Suggested susceptibility breakpoint (mg/L) | MIC Range (mg/L) | MIC50 (mg/L) | MIC90 (mg/L) | No. and percentage resistanta | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall (n = 35) | Non-invasive (n = 15) | Invasive (n = 20) | Overall (n = 35) | Non-invasive (n = 15) | Invasive (n = 20) | Overall (n = 35) | Non-invasive (n = 15) | Invasive (n = 20) | Overall (n = 35) | Non-invasive (n = 15) | Invasive (n = 20) | p-value | ||
| Levofloxacin | ≤2 | 0.5–32 | 0.5–2 | 0.5–32 | 1 | 1 | 2 | 8 | 2 | 16 | 9 (25.7) | 0 (0.0) | 9 (45.0) | 0.004 |
| Tetracycline | ≤2 | 0.016–32 | 0.25–32 | 0.016–16 | 0.5 | 1 | 0.25 | 8 | 2 | 8 | 5 (14.3) | 1 (6.7) | 4 (20.0) | 0.356 |
| Clindamycin | ≤0.125 | 0.004–128 | 0.016–32 | 0.004–128 | 0.031 | 0.031 | 0.031 | 0.125 | 0.125 | 0.063 | 3 (8.6) | 1 (6.7) | 2 (10.0) | 1 |
| Erythromycin | ≤0.5 (Mpn) | 4 to ≥256 | 8 to ≥256 | 4 to ≥256 | 32 | 32 | 32 | ≥256 | 128 | ≥256 | 35 (100.0) | 15 (100.0) | 20 (100.0) | 1 |
| Totalb | 12 (34.3) | 2 (13.3) | 10 (50.0) | 0.034 | ||||||||||
a
Susceptibility was designated using suggested MIC breakpoints determined by this study for levofloxacin (≤2 mg/L), tetracycline (≤2 mg/L), and clindamycin (≤0.125 mg/L). The breakpoint for erythromycin was adopted from the Clinical and Laboratory Standards Institute reference for M. pneumoniae (Mpn, S ≤ 0.5 mg/L).
b
Erythromycin was excluded in overall resistance rate calculation.