Table 4.
Tetracycline MIC and genetic alterations.
| Isolate | Tet MIC (mg/L) | TetM | 16S rRNA gene alteration (E. coli numbering) |
|---|---|---|---|
| ATCC 23064 | 0.5 | - | - |
| ATCC 14277 | 1 | - | - |
| 63019 | 0.016 | - | G974T (1023) |
| 49906 | 0.031 | - | C936T (986); A1355G (1408) |
| 73273 | 0.063 | Pos | C223T (264); C368T (409) |
| 73363 | 0.063 | Pos | - |
| 83735 | 0.063 | - | G985A (1039) |
| 62771 | 0.125 | - | - |
| 69499 | 0.125 | - | - |
| 78192 | 0.125 | - | - |
| 81314 | 0.125 | - | - |
| 59240 | 0.25 | Pos | - |
| 72036 | 0.25 | - | - |
| 48759 | 0.5 | - | C585T (625) |
| 59228 | 0.5 | Pos | - |
| 59262 | 0.5 | - | - |
| 59263 | 0.5 | Pos | G984A (1038); G1213T (1267) |
| 59272 | 0.5 | Pos | - |
| 59838 | 0.5 | - | - |
| 59229 | 1 | Pos | - |
| 59247 | 1 | Pos | - |
| 59266 | 1 | Pos | - |
| 59271 | 1 | - | - |
| 82217 | 1 | - | C1396T (1449) |
| 84893 | 1 | - | - |
| 59258 | 2 | Pos | G224A (265) |
| 59260 | 2 | Pos | C304T (345); A915G (mixed, 965); G923A (973) |
| 59283 | 2 | Pos | A915G (965) |
| 82746 | 2 | - | - |
| 84726 | 2 | - | - |
| 72904* | 4 | - | A915T (965); C1141T (1195) |
| 80422* | 4 | - | A915T (965); C1141T (1195) |
| 82061* | 4 | - | A915T (965); C1141T (1195) |
| 83426 | 4 | - | G376A (417); A915G (965) |
| 85051* | 4 | - | A915T (965); C1141T (1195) |
| 72114 | 8 | - | A915T (965); A919C (969); C1141T (1195) |
| 84850 | 8 | - | T6C (41); A915G (965); A917T (967); A1406G (1462) |
| 84114 | 16 | - | G659A (519); G916T (966); A917C (967) |
| 59243 | 32 | Pos | A915G (965); G1213T (1267) |
Both ATCC strains 23064 and 14277 are used as reference. Mutations known to be associated with resistance are bolded. Tet, tetracycline.
*
Sequential isolates from the same patient after isolate 72114.