FIGURE 1.

Schematic representation of the complexes discussed herein, with respect to basic components and spatial distribution in axonal growth cones (left) and synaptic spines (right). Note the regulatory complexes that have been reported and could potentially affect local protein synthesis and cytoskeletal rearrangements in both compartments, like the DCC receptor and the Mena-RNP. ZBP1 and the APC-RNP have been extensively studied in axons, whereas the CYFIP1-FMRP-RNP has been primarily examined in synapses. Potential crosstalk between the pathways remains elusive, although the direct or indirect association of receptors like DCC and Robo with Mena, or the WRC has been previously reported (Menzies et al., 2004; McConnell et al., 2016; Zou et al., 2018).