Fig. 7.

Noncoding RNA is associated with the regulation of pyroptosis. miR-148a inhibits the expression of TXNIP to suppress NLRP3 inflammasome activation, which is reversed by elevated FoxO1 expression induced by alcohol treatment. Additionally, microRNA-9 functions on ELAVL1 to suppress the expression of TNF-α, which inhibits pyroptosis by preventing NLRP3 inflammasome activation in a hyperglycemic environment. Similarly, MALAT1 downregulates the expression of miR-23c to induce ELAVL1 expression. Finally, the lncRNA Neat1, activated by HIF-2α, activates the NLRP3 inflammasome and directly interacts with caspase-1 p20 subunits to yield mature caspase-1