Fig. 9.

Prospects for pyroptosis in anticancer therapy. The therapeutic feasibility and potential of manipulating pyroptosis as an anticancer therapy have recently been explored. Chemotherapy is still the most common form of cancer treatment, as it elicits tumor cell death by triggering pyroptosis. In addition, some novel target and delivery methods have been developed, such as chimeric antigen receptor engineered T cells (CAR-T), chimeric costimulatory converting receptor (CCCR), immune stimulation, bioorthogonal chemical systems, and epigenetic methods, all of which can effectively induce pyroptosis in tumor cells