Table 2.
Meta-analysis of diet and supplements with risk of dementia.
| Heterogeneity | ||||||||
|---|---|---|---|---|---|---|---|---|
| Dementia/AD | Diet and supplements vitamin E | Studies ( n ) | OR | 95% CI | P -value | Model | I2 (%) | P -value |
| Vitamin E | 15 | 0.79 | 0.70–0.88 | 0.012 | Random | 35.0 | 0.071 | |
| Dietary Vitamin E | 8 | 0.78 | 0.65–0.95 | 0.004 | Random | 59.2 | 0.016 | |
| Vitamin E supplements | 9 | 0.83 | 0.73–0.94 | 0.000 | Random | 30.6 | 0.173 | |
| Dementia | Cohort study | 14 | 0.79 | 0.69–0.89 | 0.000 | Random | 48.3 | 0.022 |
| Case-control study | 4 | 0.76 | 0.47–1.24 | 0.274 | Random | 0.0 | 0.799 | |
| >7 | 8 | 0.85 | 0.75–0.97 | 0.017 | Random | 0.0 | 0.445 | |
| < =7 | 10 | 0.76 | 0.65–0.89 | 0.000 | Random | 49.4 | 0.038 | |
| Vitamin E | 9 | 0.78 | 0.64–0.94 | 0.001 | Random | 36.9 | 0.123 | |
| Dietary Vitamin E | 5 | 0.83 | 0.64–1.09 | 0.182 | Random | 60.2 | 0.040 | |
| AD | Vitamin E supplements | 3 | 0.67 | 0.47–0.96 | 0.031 | Random | 0.0 | 0.460 |
| Cohort study | 8 | 0.77 | 0.63–0.94 | 0.010 | Random | 42.3 | 0.097 | |
| >7 | 3 | 0.63 | 0.36–1.15 | 0.136 | Random | 37.7 | 0.201 | |
| < =7 | 6 | 0.80 | 0.65–0.98 | 0.035 | Random | 44.1 | 0.111 | |