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The therapeutic target of various host-response modulators including the government ‘approved’ non-antibacterial doxycycline formulation (SDD), as well as CMTs, such as inhibitors of matrix metalloproteinase (MMP) and of inflammatory mediators. IL, interleukin; PGE2, prostaglandin E2; PUFAs, polyunsaturated fatty acids. Significantly modified from Golub LM, Ryan ME and Williams RC (18). Modulation of the host response in the treatment of periodontitis. Dent. Today 17:102-109.
