Table 2.

Additional diagnostic criteria for metabolic syndrome (MetS)

	EGIR21	AACE20
Required criteria	Non-diabetic with IR or fasting hyperinsulinemia (highest quartile) and two or more of the following	No specific criteria required; diagnosis is left to clinical judgment based on the presence (or absence) of the following
Additional criteria	•FPG ≥ 6.1 mmol/L or IFG •BP ≥ 140/90 mmHg or antihypertensive drug treatment •TG ≥ 2.0 mmol/L or HDLc < 1.0 mmol/L or treatment for dyslipidemia •WC ≥ 94 cm (M) or ≥80 cm (F)	•Glucose intolerance (IFG or IGT) •Abnormal uric acid metabolism (plasma uric acid concentration or renal uric acid clearance) •Dyslipidemia (TG, HDLc, LDL-particle diameter, postprandial accumulation of TG-rich lipoproteins) •Haemodynamic changes (SNS activity, renal sodium retention, blood pressure) •Prothrombotic factors (PAI-1, fibrinogen) •Markers of inflammation (CRP, WBC, etc.) •Endothelial dysfunction (mononuclear cell adhesion, plasma concentration of cellular adhesion molecules, plasma concentration of asymmetric dimethylarginine, endothelial-dependent vasodilatation)

BP, blood pressure; CRP, C-reactive protein; F, female; FPG, fasting plasma glucose; HDLc, HDL cholesterol; IFG, impaired fasting glucose; IGT, impaired glucose tolerance; IR, insulin resistance; LDL, low-density lipoprotein; M, male; PAI-1, plasminogen activator inhibitor-1; SNS, sympathetic nervous system; TG, triglycerides; WBC, white blood cells; WC, waist circumference.